Section for Dementia Research, Department of Cellular Neurology, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.
Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
Alzheimers Dement. 2018 Nov;14(11):1427-1437. doi: 10.1016/j.jalz.2018.06.3059. Epub 2018 Sep 25.
Little is known about effects of physical activity (PA) in genetically driven early-onset autosomal dominant Alzheimer's disease (AD).
A total of 372 individuals participating at the Dominantly Inherited Alzheimer Network study were examined to evaluate the cross-sectional relationship of PA with cognitive performance, functional status, cognitive decline, and AD biomarkers in cerebrospinal fluid. Mutation carriers were categorized as high or low exercisers according to WHO recommendations.
Mutation carriers with high PA showed significantly better cognitive and functional performance and significantly less AD-like pathology in cerebrospinal fluid than individuals with low PA. Mutation carriers with high PA scored 3.4 points better on Mini Mental State Examination at expected symptom onset and fulfilled the diagnosis of very mild dementia 15.1 years later compared with low exercisers.
These results support a beneficial effect of PA on cognition and AD pathology even in individuals with genetically driven autosomal dominant AD.
对于遗传驱动的早发性常染色体显性阿尔茨海默病（AD）中体力活动（PA）的影响知之甚少。
共检查了 372 名参与显性遗传性阿尔茨海默病网络研究的个体，以评估 PA 与认知表现、功能状态、认知下降和脑脊液中 AD 生物标志物的横断面关系。根据世界卫生组织的建议，将突变携带者分为高或低体力活动者。
高 PA 的突变携带者在认知和功能表现方面明显更好，脑脊液中的 AD 样病理学明显更少，而低 PA 的个体则不然。与低体力活动者相比，高 PA 的突变携带者在预期症状出现时的 Mini-Mental State Examination 中得分高出 3.4 分，并且在 15.1 年后符合非常轻度痴呆的诊断标准。
这些结果支持 PA 对认知和 AD 病理的有益影响，即使在遗传驱动的常染色体显性 AD 个体中也是如此。
