多重耐药肺炎球菌对新型喹啉类抗生素、萘啶酸、香豆霉素和新生霉素的敏感性。
Susceptibility of multiply antibiotic-resistant pneumococci to the new quinoline antibiotics, nalidixic acid, coumermycin, and novobiocin.
作者信息
Gombert M E, Aulicino T M
出版信息
Antimicrob Agents Chemother. 1984 Dec;26(6):933-4. doi: 10.1128/AAC.26.6.933.
Abstract
The susceptibility of 10 multiply antibiotic-resistant strains of Streptococcus pneumoniae to several quinoline antibiotics and to coumermycin, novobiocin, and penicillin was determined. The MIC of penicillin for all test isolates was greater than or equal to 4 micrograms/ml. Ciprofloxacin was the most active quinoline derivative tested, followed by norfloxacin. These isolates of S. pneumoniae were not inhibited by the remaining quinolines at achievable concentrations in serum. Coumermycin and ciprofloxacin were the most active antibiotics tested in this study.
摘要
测定了10株多重耐药肺炎链球菌对几种喹啉类抗生素以及香豆霉素、新生霉素和青霉素的敏感性。所有测试菌株对青霉素的最低抑菌浓度大于或等于4微克/毫升。环丙沙星是所测试的喹啉衍生物中活性最强的，其次是诺氟沙星。在血清可达到的浓度下，其余喹啉类药物对这些肺炎链球菌分离株没有抑制作用。香豆霉素和环丙沙星是本研究中活性最强的抗生素。
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