Linköping University, Department of Biomedical Engineering, Linköping, Sweden.
Linköping University, Department of Medical and Health Sciences, Linköping, Sweden.
J Biomed Opt. 2018 Sep;23(12):1-6. doi: 10.1117/1.JBO.23.12.121608.
We have determined in vivo optical scattering properties of normal human skin in 1734 subjects, mostly with fair skin type, within the Swedish CArdioPulmonary bioImage Study. The measurements were performed with a noninvasive system, integrating spatially resolved diffuse reflectance spectroscopy and laser Doppler flowmetry. Data were analyzed with an inverse Monte Carlo algorithm, accounting for both scattering, geometrical, and absorbing properties of the tissue. The reduced scattering coefficient was found to decrease from 3.16 ± 0.72 to 1.13 ± 0.27 mm-1 (mean ± SD) in the 475- to 850-nm wavelength range. There was a negative correlation between the reduced scattering coefficient and age, and a significant difference between men and women in the reduced scattering coefficient as well as in the fraction of small scattering particles. This large study on tissue scattering with mean values and normal variation can serve as a reference when designing diagnostic techniques or when evaluating the effect of therapeutic optical systems.
我们已经在瑞典心肺生物影像研究中，在 1734 名对象（主要是皮肤白皙的人群）中确定了正常人体皮肤的体内光学散射特性。这些测量是使用一种非侵入性系统进行的，该系统结合了空间分辨漫反射光谱和激光多普勒流量测量。数据用逆蒙特卡罗算法进行了分析，该算法考虑了组织的散射、几何和吸收特性。在 475 到 850nm 的波长范围内，降低的散射系数从 3.16 ± 0.72 降低到 1.13 ± 0.27mm-1（平均值 ± 标准差）。降低的散射系数与年龄呈负相关，并且男性和女性之间在降低的散射系数以及小散射颗粒的分数方面存在显著差异。这项关于组织散射的大型研究提供了平均值和正常变化，可以作为设计诊断技术或评估治疗性光学系统效果的参考。
