Eyre-Brook I A, Dundas S
Gut. 1986 Dec;27(12):1419-25. doi: 10.1136/gut.27.12.1419.
Evidence of cytomegalovirus infection has been sought in a consecutive series of patients requiring colonic resection for idiopathic inflammatory bowel disease confined to the colon. Colonic tissue was examined by light and electron microscopy for cytomegalovirus inclusion bodies and cytomegalovirus antigen was sought using an immunoperoxidase technique. Cytomegalovirus infection was identified in three of 26 patients studied, but the infection did not appear to influence the course of the colitis. Although all three patients with cytomegalovirus infection needed urgent surgery, none had toxic megacolon. No evidence of cytomegalovirus infection was found in three other patients with toxic megacolon. One patient, who had a rising titre of IgG to cytomegalovirus received treatment with acyclovir which eradicated cytomegalovirus from the colon without altering the course of the colitis.
在一系列因局限于结肠的特发性炎症性肠病而需要进行结肠切除术的连续患者中，探寻了巨细胞病毒感染的证据。通过光学显微镜和电子显微镜检查结肠组织中的巨细胞病毒包涵体，并使用免疫过氧化物酶技术寻找巨细胞病毒抗原。在研究的26例患者中，有3例被确定为巨细胞病毒感染，但该感染似乎并未影响结肠炎的病程。尽管所有3例巨细胞病毒感染患者都需要紧急手术，但均无中毒性巨结肠。在另外3例中毒性巨结肠患者中未发现巨细胞病毒感染的证据。1例对巨细胞病毒IgG滴度升高的患者接受了阿昔洛韦治疗，该治疗清除了结肠中的巨细胞病毒，但未改变结肠炎的病程。
