经颅直流电刺激促进中风后运动功能恢复：挑战与机遇
Transcranial Direct Current Stimulation for Poststroke Motor Recovery: Challenges and Opportunities.
作者信息
Feng Wuwei, Kautz Steven A, Schlaug Gottfried, Meinzer Caitlyn, George Mark S, Chhatbar Pratik Y
机构信息
Departments of Neurology and Health Science and Research, Medical University of South Carolina, 96 Jonathan Lucas Street, Charleston, SC 29425(∗).
Department of Health Science and Research, Medical University of South Carolina, Charleston; and Ralph H. Johnson VA Medical Center, Charleston, SC(†).
出版信息
PM R. 2018 Sep;10(9 Suppl 2):S157-S164. doi: 10.1016/j.pmrj.2018.04.012.
Abstract
There has been a renewed research interest in transcranial direct current stimulation (tDCS) as an adjunctive tool for poststroke motor recovery as it has a neuro-modulatory effect on the human cortex. However, there are barriers towards its successful application in motor recovery as several scientific issues remain unresolved, including device-related issues (ie, dose-response relationship, safety and tolerability concerns, interhemispheric imbalance model, and choice of montage) and clinical trial-related issues (ie, patient selection, timing of study, and choice of outcomes). This narrative review examines and discusses the existing challenges in using tDCS as a brain modulation tool in facilitating recovery after stroke. Potential solutions pertinent to using tDCS with the goal of harnessing the brains plasticity are proposed.
摘要
经颅直流电刺激（tDCS）作为一种辅助工具用于中风后运动恢复，因其对人类皮层具有神经调节作用，重新引发了研究兴趣。然而，它在运动恢复方面成功应用存在障碍，因为一些科学问题仍未解决，包括与设备相关的问题（即剂量反应关系、安全性和耐受性问题、半球间失衡模型以及电极放置方式的选择）和与临床试验相关的问题（即患者选择、研究时机和结果选择）。本叙述性综述探讨并讨论了在使用tDCS作为促进中风后恢复的脑调节工具时存在的现有挑战。提出了与使用tDCS以利用大脑可塑性为目标相关的潜在解决方案。
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