Université Sorbonne Paris Cité, 75019 Paris, France.
Inserm U965, Université Denis Diderot, Physiologie Clinique-Explorations Fonctionnelles, Hôpital Lariboisière, 75010 Paris, France.
Int J Mol Sci. 2018 Sep 30;19(10):2995. doi: 10.3390/ijms19102995.
While arterial reflow after a stroke represents an important challenge for better outcomes, it is also very important that sudden recanalization does not produce local oxidative and nitrogen species, deleterious for the brain and more particularly the immature brain. Our objective was to determine whether a supply in prostaglandin (Pg) E1 (Alprostadil), via its action on arterial pressure, might progressively improve cerebral reperfusion in a neonatal stroke model. Arterial blood flow was measured using ultrasonography. Rate-limiting and Pg terminal synthesizing enzymes were evaluated using reverse-transcriptase polymerase chain reaction. Our data suggests that a supply in PgE1 might delay and improve the ipsilateral reperfusion by decreasing thromboxane A synthase-1 gene, the density of reactive astrocytes and lesion volume.
虽然中风后动脉再灌注是改善预后的一个重要挑战，但突然再通也不会产生对大脑，尤其是对未成熟大脑有害的局部氧化和氮物质，这一点也非常重要。我们的目的是确定通过前列腺素 (Pg) E1（前列地尔）对动脉压的作用，是否可以逐渐改善新生卒中模型中的脑再灌注。使用超声测量动脉血流。使用逆转录聚合酶链反应评估限速酶和 Pg 末端合成酶。我们的数据表明，通过降低血栓素 A 合酶-1 基因、反应性星形胶质细胞密度和病变体积，前列腺素 E1 的供应可能会延迟和改善同侧再灌注。
