Pyke Alyssa T, Gunn Wendy, Taylor Carmel, Mackay Ian M, McMahon Jamie, Jelley Lauren, Waite Ben, May Fiona
Public Health Virology Laboratory, Forensic and Scientific Services, Coopers Plains, QLD 4108, Australia.
Institute of Environmental Science and Research Limited, Wallaceville, 5018 Upper Hutt, New Zealand.
Trop Med Infect Dis. 2018 Jul 15;3(3):75. doi: 10.3390/tropicalmed3030075.
Reference laboratories are vital for disease control and interpreting the complexities and impact of emerging pathogens. The role of these centralized facilities extends beyond routine screening capabilities to provide rapid, specific, and accurate diagnoses, advanced data analysis, consultation services, and sophisticated disease surveillance and monitoring. Within the Australasian region, the Public Health Virology Laboratory (PHV), Forensic and Scientific Services, Department of Health, Queensland Government, Australia, and the Institute of Environmental Science and Research Limited (ESR), New Zealand (NZ) perform specialised reference testing and surveillance for dengue viruses (DENVs) and other emerging arthropod-borne viruses (arboviruses), including chikungunya virus (CHIKV) and Zika virus (ZIKV). With a focus on DENV, we review the reference testing performed by PHV (2005 to 2017) and ESR (2008 to 2017). We also describe how the evolution and expansion of reference-based methodologies and the adoption of new technologies have provided the critical elements of preparedness and early detection that complement frontline public health control efforts and limit the spread of arboviruses within Australasia.
参考实验室对于疾病控制以及解读新出现病原体的复杂性和影响至关重要。这些集中化设施的作用不仅限于常规筛查能力，还包括提供快速、特异且准确的诊断、先进的数据分析、咨询服务以及精密的疾病监测。在澳大拉西亚地区，澳大利亚昆士兰州政府卫生部法医与科学服务处的公共卫生病毒学实验室（PHV）以及新西兰环境科学与研究有限公司（ESR），对登革病毒（DENV）和其他新出现的节肢动物传播病毒（虫媒病毒），包括基孔肯雅病毒（CHIKV）和寨卡病毒（ZIKV），进行专门的参考检测和监测。以登革病毒为重点，我们回顾了PHV（2005年至2017年）和ESR（2008年至2017年）所开展的参考检测。我们还描述了基于参考的方法的演变与扩展以及新技术的采用如何提供了防范和早期检测的关键要素，这些要素补充了一线公共卫生控制工作，并限制了虫媒病毒在澳大拉西亚地区的传播。
