Choudhury Gourav R, Kim Jeffrey, Frost Patrice A, Bastarrachea Raul A, Daadi Marcel M
Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, USA.
Department of Cellular and Structural Biology, UT Health Science Center, San Antonio, Texas, USA.
Brain Circ. 2016 Jul-Sep;2(3):141-145. doi: 10.4103/2394-8108.192524. Epub 2016 Oct 18.
Nonhuman primates (NHPs) are alike humans in size, behavior, physiology, biochemistry, and immunology. Given close similarities to humans, the NHP model offers exceptional opportunities to understand the biological mechanisms and translational applications with direct relevance to human conditions. Here, we evaluate the opportunities and limitations of NHPs as animal models for translational regenerative medicine. NHP models of human disease propose exceptional opportunities to advance stem cell-based therapy by addressing pertinent translational concerns related to this research. Nonetheless, the value of these primates must be carefully assessed, taking into account the expense of specialized equipment and requirement of highly specialized staff. Well-designed initial fundamental studies in small animal models are essential before translating research into NHP models and eventually into human trials. In addition, we suggest that applying a directed and collaborative approach, as seen in the evolution of stroke NHP models, will greatly benefit the translation of stem cell therapy in other NHP disease models.
非人灵长类动物（NHPs）在体型、行为、生理学、生物化学和免疫学方面与人类相似。鉴于与人类的密切相似性，NHP模型为理解与人类疾病直接相关的生物学机制和转化应用提供了绝佳机会。在此，我们评估NHP作为转化再生医学动物模型的机会和局限性。人类疾病的NHP模型通过解决与该研究相关的相关转化问题，为推进基于干细胞的治疗提供了绝佳机会。尽管如此，必须仔细评估这些灵长类动物的价值，同时考虑到专用设备的成本和对高度专业化工作人员的要求。在将研究转化为NHP模型并最终转化为人体试验之前，在小动物模型中进行精心设计的初始基础研究至关重要。此外，我们建议采用一种定向且协作的方法，就像在中风NHP模型的发展过程中所看到的那样，这将极大地有利于干细胞治疗在其他NHP疾病模型中的转化。
