Primi D, Smith C I, Hammarström L, Lundquist P G, Möller G
Clin Exp Immunol. 1977 Aug;29(2):316-9.
Supernatants from human tonsil cells cultured in the presence of the PBAs, LPS and F (ab)2 monomers of rabbit anti-human beta2-microglobulin were found to have a complement-dependent cytotoxic activity to tonsil cells of the same donors. A direct toxic effect of the PBAs on the target cells was excluded by controls. Therefore the most likely explanation for this finding is that human lymphocytes contain a subpopulation of self-reactive B cells which can be triggered by PBAs to release antibodies to self-antigens. The implications of this finding for the understanding of infections accompanied by auto-immune phenomena are discussed.
在存在PBA、LPS以及兔抗人β2-微球蛋白的F(ab)2单体的情况下培养的人扁桃体细胞的上清液，被发现对相同供体的扁桃体细胞具有补体依赖性细胞毒性活性。对照排除了PBA对靶细胞的直接毒性作用。因此，对这一发现最可能的解释是，人淋巴细胞包含一个自身反应性B细胞亚群，其可被PBA触发以释放针对自身抗原的抗体。本文讨论了这一发现对理解伴有自身免疫现象的感染的意义。
