体内和体外对大肠杆菌脂多糖耐受性的快速打破
Rapid breaking of tolerance against Escherichia coli lipopolysaccharide in vivo and in vitro.
作者信息
Sjöberg O
出版信息
J Exp Med. 1972 Apr 1;135(4):850-9. doi: 10.1084/jem.135.4.850.
Abstract
The breaking of tolerance against the lipopolysaccharide from E. coli 055:B5 was studied. It was found that immune responsiveness recovered very slowly in vivo, tolerance still existing 3 wk after the last tolerizing injection. However, if spleen cells from tolerant mice were transferred into irradiated syngeneic recipients, the tolerant state was readily broken. Spleen cells transferred 3 days after the last tolerance-maintaining dose did not respond, whereas cells transferred on day 5 or 7 responded equally well as normal spleen cells. It was also possible to break tolerance by incubating tolerant spleen cells, which did not respond after transfer, for 20 hr in vitro before transfer into irradiated recipients. The results suggest that there exist reversibly inactivated cells in tolerant animals and that these cells can be reactivated upon removal of the cells to a neutral environment.
摘要
对大肠杆菌055:B5脂多糖耐受性的打破进行了研究。发现在体内免疫反应性恢复非常缓慢，在最后一次给予耐受剂量注射后3周仍存在耐受性。然而，如果将耐受小鼠的脾细胞转移到经照射的同基因受体中，耐受状态很容易被打破。在最后一次维持耐受剂量后3天转移的脾细胞没有反应，而在第5天或第7天转移的细胞与正常脾细胞反应一样好。通过在体外将转移后无反应的耐受脾细胞培养20小时，然后再转移到经照射的受体中，也有可能打破耐受性。结果表明，在耐受动物中存在可逆性失活的细胞，并且这些细胞在转移到中性环境中后可以被重新激活。
相似文献
1
Rapid breaking of tolerance against Escherichia coli lipopolysaccharide in vivo and in vitro.体内和体外对大肠杆菌脂多糖耐受性的快速打破
J Exp Med. 1972 Apr 1;135(4):850-9. doi: 10.1084/jem.135.4.850.
2
Alloantigen persistence in induction and maintenance of transplantation tolerance.同种异体抗原在诱导和维持移植耐受中的持续性。
J Exp Med. 1987 Jun 1;165(6):1468-80. doi: 10.1084/jem.165.6.1468.
3
4
The necessity of both allogeneic antigens and stem cells for cyclophosphamide-induced skin allograft tolerance in mice.同种异体抗原和干细胞对环磷酰胺诱导的小鼠皮肤移植耐受的必要性。
Immunobiology. 1989 Feb;178(4-5):287-304. doi: 10.1016/S0171-2985(89)80053-1.
5
Recirculating, suppressor T cells in transplantation tolerance.移植耐受中的循环抑制性T细胞。
J Exp Med. 1977 May 1;145(5):1144-57. doi: 10.1084/jem.145.5.1144.
6
Spleen cells from animals tolerant to a thymus-dependent antigen can be activated by lipopolysaccharide to synthesize antibodies against the tolerogen.来自对胸腺依赖性抗原产生耐受的动物的脾细胞，可被脂多糖激活，以合成针对该耐受原的抗体。
J Exp Med. 1976 Jun 1;143(6):1429-38. doi: 10.1084/jem.143.6.1429.
7
Induction of tolerance across major barriers using a two-step method with genetic analysis of tolerance induction.采用两步法跨越主要屏障诱导耐受并对耐受诱导进行基因分析。
Immunobiology. 1989 Mar;179(1):86-108. doi: 10.1016/S0171-2985(89)80009-9.
8
Comparison of neonatally and adoptively induced transplantation tolerance in mice.小鼠新生期诱导与过继性诱导移植耐受的比较。
Folia Biol (Praha). 1980;26(3):167-75.
9
Studies on the mechanism of specific immunological unresponsiveness. II. Immunological properties of lymphoid cells from normal, immunized and immunologically unresponsive mice transferred into lethally irradiated recipients.特异性免疫无反应性机制的研究。II. 来自正常、免疫和免疫无反应小鼠的淋巴细胞转移至致死性照射受体后的免疫特性。
Z Immunitatsforsch Exp Klin Immunol. 1976 Mar;151(1-2):22-31.
10
Antigen-binding cells in mice immune or tolerant to Escherichia coli polysaccharide.对大肠杆菌多糖免疫或耐受的小鼠中的抗原结合细胞。
J Exp Med. 1971 May 1;133(5):1015-25. doi: 10.1084/jem.133.5.1015.
引用本文的文献
1
Analyses of gonococcal lipopolysaccharide in whole-cell lysates by sodium dodecyl sulfate-polyacrylamide gel electrophoresis: stable association of lipopolysaccharide with the major outer membrane protein (protein I) of Neisseria gonorrhoeae.通过十二烷基硫酸钠-聚丙烯酰胺凝胶电泳分析全细胞裂解物中的淋球菌脂多糖：脂多糖与淋病奈瑟菌主要外膜蛋白（蛋白I）的稳定结合。
Infect Immun. 1984 Oct;46(1):202-12. doi: 10.1128/iai.46.1.202-212.1984.
2
Classification of immunological unresponsiveness and tolerance.免疫无反应性与耐受性的分类。
Proc R Soc Med. 1973 May;66(5):468-71. doi: 10.1177/003591577306600524.
3
4
Regulation of autosensitization. The immune activation and specific inhibition of self-recognizing thymus-derived lymphocytes.自身致敏的调节。免疫激活以及对识别自身的胸腺来源淋巴细胞的特异性抑制。
J Exp Med. 1973 Feb 1;137(2):224-38. doi: 10.1084/jem.137.2.224.
5
Immunological tolerance in bone marrow-derived lymphocytes. I. Evidence for an intracellular mechanism of inactivation of hapten-specific precursors of antibody-forming cells.骨髓源性淋巴细胞中的免疫耐受性。I. 抗体形成细胞的半抗原特异性前体细胞失活的细胞内机制的证据。
J Exp Med. 1972 Dec 1;136(6):1404-29. doi: 10.1084/jem.136.6.1404.
6
Reversibility of high dose unresponsiveness to concanavalin A in thymus lymphocytes.胸腺淋巴细胞对刀豆蛋白A高剂量无反应性的可逆性
Immunology. 1972 Oct;23(4):637-46.
7
Effector cell blockade. A new mechanism of immune hyporeactivity induced by multivalent antigens.效应细胞阻断。一种由多价抗原诱导的免疫低反应性新机制。
J Exp Med. 1974 Jun 1;139(6):1582-98. doi: 10.1084/jem.139.6.1582.
8
Prior exposure to subimmunogenic amounts of some bacterial lipopolysaccharides induces specific immunological unresponsiveness.先前接触亚免疫原性剂量的某些细菌脂多糖会诱导特异性免疫无反应性。
Infect Immun. 1987 Dec;55(12):3085-92. doi: 10.1128/iai.55.12.3085-3092.1987.
9
Spleen cells from animals tolerant to a thymus-dependent antigen can be activated by lipopolysaccharide to synthesize antibodies against the tolerogen.来自对胸腺依赖性抗原产生耐受的动物的脾细胞，可被脂多糖激活，以合成针对该耐受原的抗体。
J Exp Med. 1976 Jun 1;143(6):1429-38. doi: 10.1084/jem.143.6.1429.
10
Evidence for the existence of self-reactive human B lymphocytes.自身反应性人类B淋巴细胞存在的证据。
Clin Exp Immunol. 1977 Aug;29(2):316-9.
本文引用的文献
1
Plaque Formation in Agar by Single Antibody-Producing Cells.琼脂中由单个抗体产生细胞形成的斑块。
Science. 1963 Apr 26;140(3565):405. doi: 10.1126/science.140.3565.405.
2
Accelerated breakdown of immunological tolerance following whole body irradiation.全身照射后免疫耐受的加速破坏。
J Immunol. 1962 May;88:613-20.
3
AN EFFECT OF THYMECTOMY ON RECOVERY FROM IMMUNOLOGICAL PARALYSIS.胸腺切除对免疫麻痹恢复的影响
Immunology. 1964 Sep;7(5):595-602.
4
STUDIES ON GLOBULIN AND ANTIBODY PRODUCTION IN MICE THYMECTOMIZED AT BIRTH.新生期切除胸腺的小鼠球蛋白和抗体生成的研究。
Immunology. 1964 Jul;7(4):419-39.
5
6
7
THYMECTOMY: PROLONGATION OF IMMUNOLOGICAL TOLERANCE IN THE ADULT MOUSE.胸腺切除术：成年小鼠免疫耐受的延长
Science. 1963 Sep 20;141(3586):1193-4. doi: 10.1126/science.141.3586.1193.
8
The loss of partial tolerance following sub-lethal irradiadition.亚致死剂量照射后部分耐受性的丧失。
Transplantation. 1963 Jan;1:107-15. doi: 10.1097/00007890-196301010-00014.
9
10
Immunization of dissociated spleen cell cultures from normal mice.对来自正常小鼠的脾细胞解离培养物进行免疫接种。
J Exp Med. 1967 Sep 1;126(3):423-42. doi: 10.1084/jem.126.3.423.
Zotero 插件