Bhattacharya S K
Psychopharmacology (Berl). 1986;90(4):499-502. doi: 10.1007/BF00174068.
Intraperitoneal administration of 9-trans-delta-tetrahydrocannabinol (THC), the major psychoactive component of cannabis, in doses of 0.5, 1.0 and 2.0 mg/kg, produced a dose-related increase in the brain concentrations of prostaglandin (PG) E2 and PGF2 alpha in male rats 4 h after THC administration, as assessed by radioimmunoassay. A time-course investigation indicated that THC (2 mg/kg, IP) induced maximal increases in rat brain concentration of both PGs 2 and 4 h after administration; PG levels declined appreciably by 8 h and were normal by 24 h. A time-course study on the hexobarbitone (100 mg/kg, IP)-induced hypnosis potentiating effect of THC (2.0 mg/kg, IP) in male rats revealed that this pharmacological action of the cannabinoid correlated well with the time-course of the THC-induced increase in rat brain PG concentrations. The present study lends support to earlier reports contending that PGs may mediate some of the central actions of THC.
腹腔注射大麻的主要精神活性成分9-反式-δ-四氢大麻酚（THC），剂量分别为0.5、1.0和2.0毫克/千克，给药4小时后，通过放射免疫分析法评估发现，雄性大鼠大脑中前列腺素（PG）E2和PGF2α的浓度呈剂量相关增加。一项时间进程研究表明，THC（2毫克/千克，腹腔注射）给药后2小时和4小时，大鼠大脑中这两种前列腺素的浓度达到最大增加；PG水平在8小时时明显下降，24小时时恢复正常。一项关于THC（2.0毫克/千克，腹腔注射）对雄性大鼠戊巴比妥（100毫克/千克，腹腔注射）诱导的催眠增强作用的时间进程研究表明，大麻素的这种药理作用与THC诱导的大鼠大脑PG浓度增加的时间进程密切相关。本研究支持了早期的报告，即前列腺素可能介导了THC的一些中枢作用。
