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本文引用的文献

1
ACTIONS OF PROSTAGLANDINS E1, E2 AND E3 ON THE CENTRAL NERVOUS SYSTEM.前列腺素E1、E2和E3对中枢神经系统的作用。
Br J Pharmacol Chemother. 1964 Feb;22(1):189-92. doi: 10.1111/j.1476-5381.1964.tb01558.x.
2
Cannabinoid content of some English reefers.
Nature. 1974 May 17;249(454):276-8. doi: 10.1038/249276a0.
3
The ring test: a quantitative method for assessing the 'cataleptic' effect of cannabis in mice.环形试验：一种评估大麻对小鼠“僵住症”效应的定量方法。
Br J Pharmacol. 1972 Dec;46(4):753-63. doi: 10.1111/j.1476-5381.1972.tb06900.x.
4
The oral activity of delta'-tetrahydrocannabinol and its dependence on prostaglandin E2.δ'-四氢大麻酚的口服活性及其对前列腺素E2的依赖性。
Br J Pharmacol. 1979 Nov;67(3):379-85. doi: 10.1111/j.1476-5381.1979.tb08691.x.

影响内源性前列腺素的条件对小鼠中δ'-四氢大麻酚活性的作用。

The effect of conditions influencing endogenous prostaglandins on the activity of delta'-tetrahydrocannabinol in mice.

作者信息

Fairbairn J W, Pickens J T

出版信息

Br J Pharmacol. 1980 Jul;69(3):491-3. doi: 10.1111/j.1476-5381.1980.tb07039.x.

DOI:10.1111/j.1476-5381.1980.tb07039.x
PMID:6249435
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2044276/
Abstract

1 The cataleptic effect of delta'-tetrahydrocannabinol (THC) depends upon the availability of the precursors of prostaglandins and the response is reduced in mice maintained on a diet deficient in arachidonic acid (AA) and restored by exogenous AA given intraperitoneally, or by feeding a normal diet. 2 In yeast-induced fever, which is accompanied by an increase in the synthesis of prostaglandins, THC shows an enhanced cataleptic effect. 3 Exposure to cold which results in depletion of prostaglandins reduces the effect of THC.

摘要
  1. δ'-四氢大麻酚（THC）的僵住效应取决于前列腺素前体的可用性，在以缺乏花生四烯酸（AA）的饮食喂养的小鼠中，该反应会减弱，而通过腹腔注射外源性AA或喂食正常饮食可使其恢复。2. 在酵母诱导的发热中，伴随着前列腺素合成增加，THC显示出增强的僵住效应。3. 暴露于寒冷导致前列腺素耗竭会降低THC的效应。