Miller D L, O'Leary T J, Girton M
Radiology. 1987 Mar;162(3):849-52. doi: 10.1148/radiology.162.3.3027747.
Radiography and microscopy were used to investigate the hepatic distribution of iodized oil injected into the hepatic artery in a rabbit VX2 tumor model. Iodized oil accumulates within hepatic metastases and in a ringlike fashion around them. Radiographic and histologic appearances were correlated, and it was concluded that ringlike deposition occurs in peritumoral sinusoids. There was no evidence that iodized oil is cleared by hepatic lymphatics. Early clearance of iodized oil into bile may possibly be caused by localized hepatic ischemia from oil microemboli or by direct phagocytosis by Kupffer cells. The remaining oil is washed through hepatic vasculature, circulates systemically, and is cleared by reticuloendothelial cells in lung, spleen, liver, and bone marrow. This mode of clearance, which has not been considered previously, may be important in the prediction of toxic effects caused by lipid and lipophilic antitumor agents administered via the hepatic artery.
在兔VX2肿瘤模型中，采用放射成像和显微镜技术研究经肝动脉注入的碘化油在肝脏中的分布情况。碘化油在肝转移瘤内及其周围呈环状蓄积。对放射成像和组织学表现进行了相关性分析，得出环状沉积发生在肿瘤周围窦状隙的结论。没有证据表明碘化油可通过肝淋巴管清除。碘化油早期排入胆汁可能是由于油微栓子导致的局部肝缺血或库普弗细胞的直接吞噬作用。剩余的油通过肝血管系统被冲走，进行全身循环，并被肺、脾、肝和骨髓中的网状内皮细胞清除。这种先前未被考虑的清除方式，可能对预测经肝动脉给药的脂质和亲脂性抗肿瘤药物所引起的毒性作用具有重要意义。
