Department of Chemistry , University of Fribourg , Chemin du Musée 9 , 1700 Fribourg , Switzerland.
Langmuir. 2019 Aug 13;35(32):10223-10232. doi: 10.1021/acs.langmuir.8b02601. Epub 2018 Oct 16.
Phospholipids are at the heart and origin of life on this planet. The possibilities in terms of phospholipid self-assembly and biological functions seem limitless. Nonetheless, nature exploits only a small fraction of the available chemical space of phospholipids. Using chemical synthesis, artificial phospholipid structures become accessible, and the study of their biophysics may reveal unprecedented properties. In this article, the recent advances by our work group in the field of chemical lipidology are summarized. The family of diamidophospholipids is discussed in detail from monolayer characterization to the formation of faceted vesicles, culminating in the template-free self-assembly of phospholipid cubes and the possible applications of vesicle origami in modern personalized medicine.
磷脂是这个星球上生命的核心和起源。就磷脂自组装和生物功能而言，其可能性似乎是无穷无尽的。尽管如此，自然界只利用了磷脂可用化学空间的一小部分。通过化学合成，人工磷脂结构变得可以获得，对它们的生物物理学研究可能揭示出前所未有的性质。在本文中，总结了我们工作组在化学脂质学领域的最新进展。详细讨论了二酰胺磷脂家族，从单层特性到有面囊泡的形成，最终实现了无模板磷脂立方自组装，以及囊泡折纸在现代个性化医学中的可能应用。
