Corrocher R, Casaril M, Bellisola G, Gabrielli G, Hulpe M, Garofoli E, Nicoli N
Tumori. 1986 Dec 31;72(6):617-9. doi: 10.1177/030089168607200613.
Twelve adults with hepatocellular carcinoma (HCC) and 8 individuals with histologically normal liver, were measured for serum selenium concentration and glutathione peroxidase (GSH-Px) of liver tissue. It was found a reduced serum selenium and liver GSH-Px in patients with HCC. Serum selenium concentration and the enzyme activity were positively correlated (p less than 0.01). The increased risk of carcinoma in selenium deficiency may be partially due to a reduced activity of GSH-Px, one of the most important scavenger enzymes of oxygen toxic radicals.
对12名肝细胞癌（HCC）成人患者和8名肝组织组织学正常的个体进行了血清硒浓度和肝组织谷胱甘肽过氧化物酶（GSH-Px）的检测。发现HCC患者血清硒和肝GSH-Px降低。血清硒浓度与酶活性呈正相关（p<0.01）。硒缺乏时癌症风险增加可能部分归因于GSH-Px活性降低，GSH-Px是氧自由基最重要的清除酶之一。
