Casaril M, Gabrielli G B, Dusi S, Nicoli N, Bellisola G, Corrocher R
Eur J Cancer Clin Oncol. 1985 Aug;21(8):941-4. doi: 10.1016/0277-5379(85)90112-9.
Glutathione peroxidase (GSH-Px) activity, one of the scavenger enzymes of oxygen active radicals, has been measured in hepatocellular carcinoma (HCC) of 17 patients and the values compared with the activity of adjacent tumor-free tissue and with those of 30 histologically normal livers. The results demonstrate a reduced GSH-Px activity in neoplastic tissue (21.19 vs 33.74 U/g prot.; P less than 0.001). However, the adjacent tumor-free liver also had a reduced activity when compared with normal tissue (23.15 vs 33.74 U/g prot.; P less than 0.01), but this value did not differ from that of HCC tissue. These data suggest that HCC might develop in a GSH-Px-deficient condition.
谷胱甘肽过氧化物酶（GSH-Px）活性是氧活性自由基清除酶之一，已在17例肝细胞癌（HCC）患者中进行检测，并将其值与相邻无肿瘤组织以及30例组织学正常肝脏的活性进行比较。结果表明，肿瘤组织中GSH-Px活性降低（21.19对33.74 U/g蛋白；P<0.001）。然而，与正常组织相比，相邻无肿瘤肝脏的活性也降低（23.15对33.74 U/g蛋白；P<0.01），但该值与HCC组织的值无差异。这些数据表明，HCC可能在GSH-Px缺乏的情况下发生。
