Burny A, Bruck C, Cleuter Y, Couez D, Deschamps J, Ghysdael J, Gregroire D, Kettmann R, Mammerickx M, Marbaix G
Princess Takamatsu Symp. 1984;15:219-27.
Bovine leukemia virus (BLV) has many structural and functional characteristics in common with the human T-lymphotropic viruses (HTLVs). The most striking feature of these retroviruses is the existence of a long open reading frame (LOR) located at the 3' side of the provirus between the right end of the 3' side of env gene and the left end of the long terminal repeat (LTR). It is believed that the LOR protein product is of critical importance in the induction process of the tumor phase of bovine leukemia. Prevention of BLV infection will be attempted by vaccination. To that aim, careful study of BLV envelope glycoprotein epitopes has shown that epitopes F, G, and H play a major role in biological activities of the virus. Their native structure depends upon glycosylation of the peptide backbone.
牛白血病病毒（BLV）与人类嗜T淋巴细胞病毒（HTLVs）具有许多共同的结构和功能特征。这些逆转录病毒最显著的特征是在原病毒的3'端，位于env基因3'端右侧与长末端重复序列（LTR）左端之间存在一个长开放阅读框（LOR）。据信，LOR蛋白产物在牛白血病肿瘤阶段的诱导过程中至关重要。将尝试通过接种疫苗来预防BLV感染。为了实现这一目标，对BLV包膜糖蛋白表位的仔细研究表明，表位F、G和H在病毒的生物学活性中起主要作用。它们的天然结构取决于肽主链的糖基化。
