Wong Melissa H Y, Fenwick Eva, Aw Ai Tee, Lamoureux Ecosse L, Seah Lay Leng
Singapore National Eye Centre (SNEC), Singapore, Singapore.
Singapore Eye Research Institute, Singapore, Singapore.
Transl Vis Sci Technol. 2018 Oct 1;7(5):14. doi: 10.1167/tvst.7.5.14. eCollection 2018 Sep.
Current instruments to assess thyroid eye disease (TED) quality of life (QoL) were not developed using modern psychometric theory and may not be applicable to Asian populations. Therefore, we developed a psychometrically robust questionnaire, the Singapore Thyroid Eye Disease Quality of Life questionnaire (STED-QoL), for assessing QoL in Asian patients.
This cross-sectional study was conducted at the Singapore National Eye Centre between 2012 and 2015. In Phase 1, content for the questionnaire was developed using qualitative methods. A total of 20 patients participated in three different focus groups. Thematic analysis was conducted to identify relevant themes from which 12 items, rated on a 5-point Likert-type scale, were generated. In Phase 2, the pilot instrument was administered to 59 TED patients and psychometric assessment of the STED-QoL was conducted using Rasch analysis.
After collapsing categories from five to four and deleting two misfitting items, we generated a 10-item STED-QoL befitting the Rasch model. The scale showed good criterion validity, with scores decreasing as severity of TED worsened: mild (1.78 logits), moderate (0.27 logits), and severe (0.92 logits). A 'Psychosocial' subscale also had adequate psychometric properties and psychosocial scores were significantly worse in those who underwent surgery for TED compared to those who had not (0.41 vs. 1.82 logits, = 0.021).
The STED-QoL is a robust 10-item questionnaire specifically developed to measure the impact of TED on QoL and psychosocial well-being in an Asian population.
QoL assessment is important for holistic management of TED patients.
目前用于评估甲状腺眼病（TED）患者生活质量（QoL）的工具并非基于现代心理测量理论开发，可能不适用于亚洲人群。因此，我们开发了一种心理测量学上可靠的问卷——新加坡甲状腺眼病生活质量问卷（STED-QoL），用于评估亚洲患者的生活质量。
这项横断面研究于2012年至2015年在新加坡国立眼科中心进行。在第一阶段，采用定性方法确定问卷内容。共有20名患者参加了三个不同的焦点小组。进行主题分析以确定相关主题，从中生成了12个项目，采用5点李克特量表评分。在第二阶段，将初步问卷应用于59名TED患者，并使用拉施分析对STED-QoL进行心理测量评估。
在将类别从5类合并为4类并删除两个不匹配的项目后，我们生成了一个符合拉施模型的10项STED-QoL。该量表显示出良好的效标效度，得分随着TED严重程度的加重而降低：轻度（1.78对数单位）、中度（0.27对数单位）和重度（0.92对数单位）。一个“心理社会”子量表也具有足够的心理测量学特性，与未接受TED手术的患者相比，接受TED手术的患者的心理社会得分明显更差（0.41对1.82对数单位，P = 0.021）。
STED-QoL是一个可靠的10项问卷，专门用于测量TED对亚洲人群生活质量和心理社会幸福感的影响。
生活质量评估对于TED患者的整体管理很重要。
