Key Laboratory for NeuroInformation of Ministry of Education, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Information in BioMedicine, University of Electronic Science and Technology of China, Chengdu, China.
Hospital of Chengdu University of TCM, Chengdu, China.
Clin EEG Neurosci. 2019 Mar;50(2):88-99. doi: 10.1177/1550059418804378. Epub 2018 Oct 3.
Obsessive-compulsive disorder (OCD) is a common inheritable psychiatric disorder characteristic of repetitive thinking, imagination (obsession), and stereotyped behaviors (compulsive). To explore whether there is an alteration of brain functional connectivity (BFC) in patients with OCD during rest, electroencephalogram (EEG) data of healthy controls (HCs) and patients with OCD were collected during rest in both eyes-closed and eyes-open states. Synchronization likelihood and graph theory were applied to construct and analyze brain functional networks of patients with OCD and HCs. Patients with OCD showed abnormal graph-theoretic parameters and impaired small world features in the alpha and beta bands. In addition, the topological analysis consistently showed that the long-range BFC of alpha rhythm was significantly reduced in the bilateral posterior areas in patients with OCD in comparison with HCs, while the BFC in the beta rhythm was significantly increased only in the eyes-open state. The findings suggest that the BFC of patients with OCD show abnormal small-world features and altered topological structure during rest, mainly in alpha and beta bands, which may provide a new insight for the diagnosis and treatment of OCD.
强迫症（OCD）是一种常见的遗传性精神障碍，其特征为重复性思维、想象（强迫观念）和刻板行为（强迫行为）。为了探讨强迫症患者在休息时大脑功能连接（BFC）是否发生改变，我们在闭眼和睁眼状态下采集了健康对照组（HCs）和强迫症患者的静息态脑电图（EEG）数据。我们应用同步似然和图论来构建和分析强迫症患者和 HCs 的脑功能网络。强迫症患者在 alpha 和 beta 频段表现出异常的图论参数和受损的小世界特征。此外，拓扑分析一致表明，与 HCs 相比，强迫症患者双侧后区的 alpha 节律的长程 BFC 显著降低，而 beta 节律的 BFC 仅在睁眼状态下显著增加。这些发现表明，强迫症患者的 BFC 在休息时表现出异常的小世界特征和拓扑结构改变，主要在 alpha 和 beta 频段，这可能为 OCD 的诊断和治疗提供新的思路。
