马立克氏病中针对肿瘤抗原的细胞介导免疫：效应细胞对抗胸腺细胞血清的敏感性以及霍乱弧菌神经氨酸酶对细胞毒性活性的增强作用。
Cell-mediated immunity to tumor antigen in Marek's disease: susceptibility of effector cells to antithymocyte serum and enhancement of cytotoxic activity by Vibrio cholerae neuraminidase.
作者信息
Sharma J M
出版信息
Infect Immun. 1977 Oct;18(1):46-51. doi: 10.1128/iai.18.1.46-51.1977.
Abstract
Spleen cells from chickens inoculated 7 to 8 days previously with Marek's disease virus were cytotoxic for 51Cr-labeled cells of a Marek's disease lymphoblastoid cell line (MSB-1 line) in a 4-h in vitro cytotoxic assay. The cytotoxic activity of spleen cells was inhibited by pretreatment with antithymocyte serum and complement, but not with complement alone or in combination with anti-bursa cell serum or normal preimmune serum. The conclusion was that the effector cell in the above cytotoxic assay was a thymus-derived lymphocyte. Also, pretreatment of target cells with Vibrio cholerae neuraminidase enhanced in vitro cytotoxic activity of effector cells. Similar enzymatic treatment of effector cells had a negligible effect on cytotoxicity.
摘要
在一项4小时的体外细胞毒性试验中，7至8天前接种马立克氏病病毒的鸡的脾细胞对马立克氏病淋巴母细胞样细胞系（MSB-1系）的51Cr标记细胞具有细胞毒性。脾细胞的细胞毒性活性可通过抗胸腺细胞血清和补体预处理来抑制，但单独使用补体或与抗法氏囊细胞血清或正常免疫前血清联合使用则不能抑制。结论是上述细胞毒性试验中的效应细胞是胸腺来源的淋巴细胞。此外，用霍乱弧菌神经氨酸酶预处理靶细胞可增强效应细胞的体外细胞毒性活性。对效应细胞进行类似的酶处理对细胞毒性的影响可忽略不计。
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引用本文的文献
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本文引用的文献
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Differences in splitting capacity of virus and V. cholerae neuraminidases on sialic acid type substrates.病毒和霍乱弧菌神经氨酸酶对唾液酸类型底物的裂解能力差异。
Biochem Biophys Res Commun. 1967 Mar 21;26(6):631-8. doi: 10.1016/s0006-291x(67)80118-9.
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Tumour specific immunogenicity of methylcholanthrene-induced sarcoma cells after incubation in neuraminidase.在神经氨酸酶中孵育后，甲基胆蒽诱导的肉瘤细胞的肿瘤特异性免疫原性。
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Cellular differentiation in the thymus. 3. Surface properties of rat thymus and lymph node cells separated on density gradients.胸腺中的细胞分化。3. 经密度梯度分离的大鼠胸腺和淋巴结细胞的表面特性。
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5
Further studies on the effect of neuraminidase on tumor cell transplantability.关于神经氨酸酶对肿瘤细胞移植性影响的进一步研究。
Tissue Antigens. 1971;1(4):153-61. doi: 10.1111/j.1399-0039.1971.tb00092.x.
6
The serologic behaviour of neuraminidase-treated lymphoid cells. Alloantigenicity and complement sensitivity.神经氨酸酶处理的淋巴细胞的血清学行为。同种抗原性和补体敏感性。
Clin Exp Immunol. 1972 Jul;11(3):441-60.
7
Resistance to Marek's disease in immunologically deficient chickens.免疫缺陷鸡对马立克氏病的抗性
Nature. 1974 Jan 11;247(5436):117-8. doi: 10.1038/247117a0.
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J Immunol. 1974 Feb;112(2):444-50.
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