Jaiswal Shubham K, Gupta Ankit, Saxena Rituja, Prasoodanan Vishnu P K, Sharma Ashok K, Mittal Parul, Roy Ankita, Shafer Aaron B A, Vijay Nagarjun, Sharma Vineet K
Metagenomics and Systems Biology Group, Department of Biological Sciences, Indian Institute of Science Education and Research Bhopal, Bhopal, India.
Forensic Science and Environmental and Life Sciences, Trent University, Peterborough, ON, Canada.
Front Genet. 2018 Sep 19;9:392. doi: 10.3389/fgene.2018.00392. eCollection 2018.
The unique ornamental features and extreme sexual traits of Peacock have always intrigued scientists and naturalists for centuries. However, the genomic basis of these phenotypes are yet unknown. Here, we report the first genome sequence and comparative analysis of peacock with the high quality genomes of chicken, turkey, duck, flycatcher and zebra finch. Genes involved in early developmental pathways including TGF-β, BMP, and Wnt signaling, which have been shown to be involved in feather patterning, bone morphogenesis, and skeletal muscle development, revealed signs of adaptive evolution and provided useful clues on the phenotypes of peacock. Innate and adaptive immune genes involved in complement system and T-cell response also showed signs of adaptive evolution in peacock suggesting their possible role in building a robust immune system which is consistent with the predictions of the Hamilton-Zuk hypothesis. This study provides novel genomic and evolutionary insights into the molecular understanding toward the phenotypic evolution of Indian peacock.
几个世纪以来，孔雀独特的观赏特征和极端的性别特征一直吸引着科学家和博物学家。然而，这些表型的基因组基础尚不清楚。在此，我们报告了孔雀的首个基因组序列，并将其与鸡、火鸡、鸭、鹟和斑胸草雀的高质量基因组进行了比较分析。参与早期发育途径的基因，包括转化生长因子-β（TGF-β）、骨形态发生蛋白（BMP）和Wnt信号通路，已被证明与羽毛图案形成、骨形态发生和骨骼肌发育有关，这些基因显示出适应性进化的迹象，并为孔雀的表型提供了有用的线索。参与补体系统和T细胞反应的先天性和适应性免疫基因在孔雀中也显示出适应性进化的迹象，表明它们可能在构建强大的免疫系统中发挥作用，这与汉密尔顿-祖克假说的预测一致。这项研究为印度孔雀表型进化的分子理解提供了新的基因组学和进化见解。
