European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Eagle Genomics Ltd., Wellcome Genome Campus, Hinxton, Cambridge CB10 1DR, UK.
Nucleic Acids Res. 2018 Jan 4;46(D1):D754-D761. doi: 10.1093/nar/gkx1098.
The Ensembl project has been aggregating, processing, integrating and redistributing genomic datasets since the initial releases of the draft human genome, with the aim of accelerating genomics research through rapid open distribution of public data. Large amounts of raw data are thus transformed into knowledge, which is made available via a multitude of channels, in particular our browser (http://www.ensembl.org). Over time, we have expanded in multiple directions. First, our resources describe multiple fields of genomics, in particular gene annotation, comparative genomics, genetics and epigenomics. Second, we cover a growing number of genome assemblies; Ensembl Release 90 contains exactly 100. Third, our databases feed simultaneously into an array of services designed around different use cases, ranging from quick browsing to genome-wide bioinformatic analysis. We present here the latest developments of the Ensembl project, with a focus on managing an increasing number of assemblies, supporting efforts in genome interpretation and improving our browser.
自人类基因组草图首次发布以来，Ensembl 项目一直在对基因组数据集进行聚合、处理、整合和再分发，旨在通过快速公开分发公共数据来加速基因组学研究。大量原始数据因此转化为知识，并通过多种渠道提供，特别是我们的浏览器（http://www.ensembl.org）。随着时间的推移，我们在多个方向上进行了扩展。首先，我们的资源描述了多个基因组学领域，特别是基因注释、比较基因组学、遗传学和表观基因组学。其次，我们涵盖了越来越多的基因组组装；Ensembl Release 90 中正好包含 100 个基因组。第三，我们的数据库同时为一系列围绕不同用例设计的服务提供支持，从快速浏览到全基因组生物信息学分析。我们在这里介绍 Ensembl 项目的最新进展，重点是管理越来越多的组装，支持基因组解释工作，并改进我们的浏览器。
