Biswas Rituparna, Halder Anirban
Department of Radiotherapy, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India.
Asian J Neurosurg. 2018 Jul-Sep;13(3):877-880. doi: 10.4103/ajns.AJNS_352_16.
Giant cell tumors (GCTs) are rare, usually affecting the epiphyses in long bones of the extremities. GCTs may be locally aggressive with a high rate of local recurrence and exhibit the potential for distant metastasis. They seldom occur in the skull, where they preferentially affect the sphenoid and temporal bones. Several case reports with follow-up describe gross total resection of skull-base GCT to be curative. Radiation therapy, although controversial, is reserved for lesions that cannot be completely resected. Here, we describe the case of an 18-year-old female with GCT of sphenoid bone who underwent subtotal resection followed by adjuvant radiotherapy, although whose radiotherapy could not be completed because of her demise due to erythema multiforme associated with phenytoin and cranial radiation therapy syndrome.
骨巨细胞瘤（GCTs）较为罕见，通常累及四肢长骨的骨骺。骨巨细胞瘤可能具有局部侵袭性，局部复发率高，并具有远处转移的可能性。它们很少发生于颅骨，在颅骨中它们更倾向于累及蝶骨和颞骨。几篇有随访的病例报告描述了颅底骨巨细胞瘤的全切除可治愈。放射治疗虽然存在争议，但适用于无法完全切除的病变。在此，我们描述了一名18岁女性蝶骨骨巨细胞瘤患者的病例，该患者接受了次全切除并辅助放疗，尽管由于她因苯妥英和颅脑放射治疗综合征相关的多形红斑死亡而未能完成放疗。
