Tsang Cynthia, Tan Savannah, Spiegelman Lindsey
University of California, Irvine, School of Medicine, Irvine, CA.
University of California, Irvine, Department of Emergency Medicine, Orange, CA.
J Educ Teach Emerg Med. 2025 Jan 31;10(1):V17-V21. doi: 10.21980/J8BM0W. eCollection 2025 Jan.
The presentation of erythema multiforme in the emergency department is relatively rare, thus recognition and rapid intervention requires a high index of suspicion. This study presents a case of a 55-year-old female with past medical history of hypertension and active endometrial cancer with recent chemotherapy treatment complaining of four days of progressive erythematous rash with associated pruritis and blistering. An exam found multiple tense, scattered vesicles with an erythematous base. The patient also demonstrated leukopenia, elevated alkaline phosphatase level, and elevated C-reactive protein level. A shave biopsy was performed and intravenous acyclovir was started for concern of varicella-zoster virus. Biopsy results favored an erythema multiforme diagnosis, and she was discharged with topical clobetasol. In addition to reviewing the presentation and intervention of erythema multiforme, this case report adds to growing literature of erythema multiforme as a delayed reaction to malignancy therapy.
Erythema multiforme, dermatology, radiotherapy.
多形红斑在急诊科的表现相对少见,因此识别和快速干预需要高度的怀疑指数。本研究报告了一例55岁女性病例,该患者有高血压病史,患有活动性子宫内膜癌且近期接受了化疗,主诉出现进行性红斑皮疹伴瘙痒和水疱四天。检查发现多个紧张、散在的水疱,基底呈红斑状。患者还出现白细胞减少、碱性磷酸酶水平升高和C反应蛋白水平升高。因怀疑水痘-带状疱疹病毒感染,进行了削除活检并开始静脉注射阿昔洛韦。活检结果支持多形红斑的诊断,患者出院时外用氯倍他索。除了回顾多形红斑的表现和干预措施外,本病例报告还补充了越来越多关于多形红斑作为恶性肿瘤治疗延迟反应的文献。
多形红斑、皮肤病学、放射治疗。