Department of Woman and Child Health, Referral Centre for Food Allergy Diagnosis and Treatment Veneto Region, University of Padua, Via Giustiniani 3, 35128, Padua, Italy.
Allergy Unit, Bambino Gesù Children's Hospital, IRCCS, Piazza Sant'Onofrio 4, 00165, Rome, Italy.
Curr Allergy Asthma Rep. 2018 Oct 3;18(11):64. doi: 10.1007/s11882-018-0816-4.
To familiarize the reader with the concept of precision medicine in food allergy by dealing with the current biomarkers for the diagnosis, prognosis, and management of the disease.
Many efforts have been devoted in order to characterize reliable biomarkers able to identify specific phenotypes and endotypes in food allergy. Specific IgE (sIgE), sIgE/total IgE ratios, and T cell assays are just a few candidates that have been investigated over time. With the advent of omics sciences, a new era is commencing. A better understanding of pathogenesis of food allergy and mechanisms of action of the different therapeutic options will allow the accurate selection of the appropriate patient. In the near future, advances in technologies and data interpretation will allow a better understanding of the pathogenesis of food allergy and the identification of proper biomarkers for a personalized treatment tailored on the specific patient's profile.
通过探讨当前用于诊断、预后和管理食物过敏的生物标志物，使读者熟悉精准医学在食物过敏中的概念。
为了鉴定能识别食物过敏特异性表型和内型的可靠生物标志物，人们付出了很多努力。特异性 IgE（sIgE）、sIgE/总 IgE 比值和 T 细胞检测只是过去一段时间以来的一些候选标志物。随着组学科学的出现，一个新时代正在开启。对食物过敏发病机制和不同治疗选择作用机制的更好理解将允许对合适的患者进行准确选择。在不久的将来，技术进步和数据解释将使人们更好地了解食物过敏的发病机制，并确定适当的生物标志物，以针对特定患者的具体情况进行个性化治疗。
