Kabil Shaimaa E, Abdelshafy Rania, Ahmed Ahmed Ismail Abbas, Zahran Alhassan Mostafa, Attalah Mahmoud, Sallam Yossra, El Lateef Aisha Ghanem Abd
E. N. T Department, Faculty of Medicine Cairo, Al-Azhar University, Cairo, Egypt.
Pediatric Department, Faculty of Medicine Cairo, Al-Azhar University, Cairo, Egypt.
J Multidiscip Healthc. 2023 Mar 27;16:811-817. doi: 10.2147/JMDH.S401937. eCollection 2023.
Language disorders (LD) in autism spectrum disorders (ASD) are highly variable and has a severe impact on the level of functioning in autistic children. Early diagnosis of these language disorders is essential for early interventions for children at risk. The electrophysiological measurements are considered valuable tools for determining language disabilities in children with ASD. This study aimed to study and compare ABR and MMN in autistic children with language disorders.
This study included a group of typically developing children and a group of children diagnosed with autistic spectrum disorders and language disorders. Both groups were matching according to age and gender. After confirming bilateral normal peripheral hearing sensitivity, ABR was done and both absolute and interpeak wave latencies were correlated. MMN using frequency oddball paradigms were also obtained and correlated.
More abnormalities were reported in ABR test results in the form of delayed absolute latencies and prolonged interpeak intervals. Also, we reported prolonged latencies of MMN. Consequently, both ABR and MMN are complementary test in evaluating autistic children with language disorders.
Our results support the hypothesis of remarkable dysfunction in basic auditory sound processing that may impact the linguistic development of autistic children.
自闭症谱系障碍（ASD）中的语言障碍（LD）具有高度变异性，对自闭症儿童的功能水平有严重影响。这些语言障碍的早期诊断对于有风险儿童的早期干预至关重要。电生理测量被认为是确定ASD儿童语言障碍的有价值工具。本研究旨在研究和比较患有语言障碍的自闭症儿童的听性脑干反应（ABR）和失匹配负波（MMN）。
本研究包括一组发育正常的儿童和一组被诊断为自闭症谱系障碍及语言障碍的儿童。两组在年龄和性别上相匹配。在确认双侧外周听力敏感度正常后，进行ABR检测，并对绝对波潜伏期和峰间潜伏期进行相关性分析。还采用频率偏差范式获得MMN并进行相关性分析。
ABR测试结果显示出更多异常，表现为绝对潜伏期延迟和峰间间期延长。此外，我们还报告了MMN潜伏期延长。因此，ABR和MMN在评估患有语言障碍的自闭症儿童时是互补性测试。
我们的结果支持以下假设，即基本听觉声音处理存在显著功能障碍，这可能会影响自闭症儿童的语言发展。
