Blake Glen M, Siddique Musib, Frost Michelle L, Moore Amelia E B, Fogelman Ignac
Osteoporosis Unit, King's College London, King's Health Partners, Guy's Hospital, London SE1 9RT, UK.
Department of Nuclear Medicine, King's College London, King's Health Partners, Guy's Hospital, London SE1 9RT, UK.
PET Clin. 2012 Jul;7(3):275-91. doi: 10.1016/j.cpet.2012.04.001. Epub 2012 May 31.
Studies of bone remodeling using bone biopsy and biochemical markers of bone turnover measured in serum and urine are important for investigating how new treatments for osteoporosis affect bone metabolism. Positron emission tomography with (18)F sodium fluoride ((18)F NaF PET) for studying bone metabolism complements these conventional methods. Unlike biochemical markers, which measure the integrated response to treatment across the whole skeleton, (18)F NaF PET can distinguish changes occurring at sites of clinically important osteoporotic fractures. Future studies using (18)F NaF PET may illuminate current clinical problems, such as the possible association between long-term treatment with bisphosphonates and atypical fractures of the femur.
利用骨活检以及血清和尿液中骨转换生化标志物对骨重塑进行研究，对于探究骨质疏松症的新治疗方法如何影响骨代谢具有重要意义。使用（18）F 氟化钠正电子发射断层扫描（（18）F NaF PET）来研究骨代谢，对这些传统方法起到了补充作用。与测量整个骨骼对治疗的综合反应的生化标志物不同，（18）F NaF PET 能够区分在具有临床重要意义的骨质疏松性骨折部位发生的变化。未来使用（18）F NaF PET 进行的研究可能会阐明当前的临床问题，比如双膦酸盐长期治疗与股骨非典型骨折之间可能存在的关联。
