Frol'kis I V
Biull Eksp Biol Med. 1987 Feb;103(2):133-5.
Vasopressin action on isolated strips of the femoral artery was studied in mature and old rats. Vasopressin has been shown to depolarize smooth muscle cells (SMC) membranes, causing the tonic contraction of the strips. SMC sensitivity to vasopressin in old animals was increased, electrical and contractile reactions were also enhanced. Peculiar tachyphylaxia in response to vasopressin has been found in SMC of mature animals. In old animals SMC tachyphylaxia was far less expressed than in mature ones. Two types of vasopressin receptors (V1-exciting and V2-inhibitory) in vascular SMC were suggested. Vasopressin does not influence cAMP content of the femoral artery in mature and old animals. Specific features of SMC reactions to vasopressin in old animals may underlie the mechanisms of cardiovascular pathology in old age.
研究了血管加压素对成熟大鼠和老年大鼠离体股动脉条的作用。血管加压素已被证明可使平滑肌细胞膜去极化，导致动脉条的强直性收缩。老年动物的平滑肌细胞对血管加压素的敏感性增加，电反应和收缩反应也增强。在成熟动物的平滑肌细胞中发现了对血管加压素的特殊快速耐受性。在老年动物中，平滑肌细胞的快速耐受性远不如成熟动物明显。有人提出血管平滑肌细胞中有两种类型的血管加压素受体（V1-兴奋性和V2-抑制性）。血管加压素对成熟和老年动物股动脉的环磷酸腺苷（cAMP）含量没有影响。老年动物平滑肌细胞对血管加压素反应的特异性特征可能是老年心血管病理机制的基础。
