Lee Kwan Ho, Kim Eun Young, Yun Ji Sup, Park Yong Lai, Do Sung-Im, Chae Seoung Wan, Park Chan Heun
Department of Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul, 03181, South Korea.
Department of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul, 03181, South Korea.
BMC Cancer. 2018 Oct 1;18(1):938. doi: 10.1186/s12885-018-4832-5.
Carcinogenesis and tumor growth are associated with chronic inflammation and the host immune system. Here, we investigated the clinical significance and relationship between tumor-infiltrating lymphocytes (TILs) and hematologic parameters in patients with breast cancer.
Invasive ductal breast cancer patients (N = 145) who underwent surgery were retrospectively evaluated. Samples were obtained using a core needle biopsy for CD8+, FOXP3+ TIL assessment. Blood lymphocytes, neutrophils, monocytes, and platelets were obtained by peripheral venous punctures.
CD8 + TILs were significantly associated with absolute lymphocyte count (ALC) and the absolute monocyte count (AMC). Low LMR (ALC/AMC) (cut-off - 5.3, range = 0.73-12.31) was associated with poor overall survival (OS) (p = 0.010), disease-free survival (DFS) (p = 0.005). However, in subgroup analysis, LMR did not have any value as a prognostic factor in HER2-positive breast cancers. TILs had different prognostic impacts across breast cancer subtypes, although they were not statistically significant. The treatment response after NAC tended to improve in breast cancer patients with high FOXP3+ TILs, low NLR (neutrophil count/ALC) (FOXP3 p for trend = 0.006, NLR p for trend = 0.063).
A relevance between TILs and hematologic parameters in breast cancer was demonstrated. The influence of the immune system on breast cancer progression may differ by subtype.
癌症发生和肿瘤生长与慢性炎症及宿主免疫系统相关。在此，我们研究了乳腺癌患者肿瘤浸润淋巴细胞（TILs）与血液学参数之间的临床意义及关系。
对145例行手术治疗的浸润性导管癌患者进行回顾性评估。采用粗针活检获取样本以评估CD8 +、FOXP3 + TILs。通过外周静脉穿刺获取血液淋巴细胞、中性粒细胞、单核细胞和血小板。
CD8 + TILs与绝对淋巴细胞计数（ALC）和绝对单核细胞计数（AMC）显著相关。低LMR（ALC/AMC）（临界值 - 5.3，范围 = 0.73 - 12.31）与总生存期（OS）较差（p = 0.010）、无病生存期（DFS）较差（p = 0.005）相关。然而，在亚组分析中，LMR在HER2阳性乳腺癌中作为预后因素无任何价值。TILs在不同乳腺癌亚型中具有不同的预后影响，尽管无统计学意义。新辅助化疗（NAC）后，FOXP3 + TILs高、中性粒细胞与淋巴细胞比值（NLR）低（中性粒细胞计数/ALC）的乳腺癌患者治疗反应倾向于改善（FOXP3趋势p = 0.006，NLR趋势p = 0.063）。
证明了乳腺癌中TILs与血液学参数之间的相关性。免疫系统对乳腺癌进展的影响可能因亚型而异。
