Institut des Matériaux Jean Rouxel (IMN), Université de Nantes, CNRS UMR 6502, 2 rue de la Houssinière B.P. 32229, 44322 Nantes Cedex 3, France.
Laboratoire Léon Brillouin, CEA-CNRS UMR 12, CEA Saclay, Université Paris-Saclay, 91191 Gif sur Yvette Cedex, France; Laboratoire de Physique des Solides, UMR 8502 CNRS-Université Paris Sud, Université Paris-Saclay, 91405 Orsay Cedex, France.
Carbohydr Polym. 2018 Dec 15;202:404-408. doi: 10.1016/j.carbpol.2018.08.143. Epub 2018 Sep 5.
Silanized hydroxypropyl methylcellulose based hydrogels were developed for cartilage and intervertebral disc tissue engineering. Herein, study of dynamics of confined water showed two different populations, identified as hydration and bulk-like water. The diffusion coefficient showed that bulk-like water diffuses over distances ∼10 μm without being affected by the hydrogel matrix. Addition of silica nanofibers leads to improved mechanical properties and enhanced diffusion coefficient. Good diffusion within hydrogels is essential for the application.
硅烷化羟丙基甲基纤维素水凝胶被开发用于软骨和椎间盘组织工程。本文研究了受限水的动力学，发现了两种不同的水，分别为水合水和类本体水。扩散系数表明，类本体水在不受水凝胶基质影响的情况下扩散约 10μm 的距离。添加纳米二氧化硅纤维可提高力学性能和增强扩散系数。水凝胶内的良好扩散对于应用至关重要。
