Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg 40530, Sweden.
Chem Commun (Camb). 2018 Oct 18;54(84):11885-11888. doi: 10.1039/c8cc06550k.
We describe a potential molecular mechanism explaining how DNA methylation contributes to biological regulation. Using molecular dynamics together with a new torsional restraint, we identify the impact of methylation on DNA response to torsional stress. We observe that, depending on the sequence, DNA methylation hinders overwinding or underwinding molecular transitions.
我们描述了一种潜在的分子机制，解释了 DNA 甲基化如何有助于生物调控。我们使用分子动力学和一种新的扭转约束，来确定甲基化对 DNA 响应扭转应力的影响。我们观察到，取决于序列，DNA 甲基化会阻碍过度缠绕或欠缠绕的分子转变。
