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利用无虹膜-威尔姆斯瘤相关缺失对11号染色体短臂上的DNA探针进行区域定位。

Regional localization of DNA probes on the short arm of chromosome 11 using aniridia-Wilms' tumor-associated deletions.

作者信息

Mannens M, Slater R M, Heyting C, Geurts van Kessel A, Goedde-Salz E, Frants R R, Van Ommen G J, Pearson P L

出版信息

Hum Genet. 1987 Feb;75(2):180-7. doi: 10.1007/BF00591083.

DOI:10.1007/BF00591083
PMID:3028933
Abstract

We are interested in the precise localization of various DNA probes on the short arm of chromosome 11 for our research on the aniridia-Wilms' tumor association (AWTA), assigned to region 11p13 (Knudson and Strong 1972; Riccardi et al. 1978). For this purpose we have screened lymphocyte DNA and material derived from somatic cell hybrids from individuals with constitutional 11p deletions with a range of available probes: D11S12; calcitonin/CGRP (CALC1/CALC2); insulin (INS); Harvey ras 1 (HRAS 1); beta-globin gene cluster (HBBC); human insulin-like growth factor 2 (IGF-2); parathyroid hormone (PTH); human pepsinogen A (PGA). Using this material, it has been possible to map all probes used, except insulin, outside the region 11p111-p15.1, resulting in an SRO (same regional overlap) of 11p15.1-p15.5 for most probes. We found an SRO for PGA of 11p111-q12 and an SRO for CALC2 of 11p15.1-p15.5 or 11p111-q12. We have localised the insulin gene to band 11p15.1.

摘要

我们对11号染色体短臂上各种DNA探针的精确定位感兴趣，以便进行我们关于无虹膜-威尔姆斯瘤关联（AWTA）的研究，该关联被定位于11p13区域（Knudson和Strong，1972年；Riccardi等人，1978年）。为此，我们用一系列可用探针筛选了淋巴细胞DNA以及来自11号染色体短臂先天性缺失个体的体细胞杂种材料：D11S12；降钙素/CGRP（CALC1/CALC2）；胰岛素（INS）；哈维鼠肉瘤病毒癌基因1（HRAS 1）；β-珠蛋白基因簇（HBBC）；人胰岛素样生长因子2（IGF-2）；甲状旁腺激素（PTH）；人胃蛋白酶原A（PGA）。利用这些材料，除胰岛素外，已将所有使用的探针定位在11p111-p15.1区域之外，大多数探针的最小重叠区域（SRO）为11p15.1-p15.5。我们发现PGA的SRO为11p111-q12，CALC2的SRO为11p15.1-p15.5或11p111-q12。我们已将胰岛素基因定位到11p15.1带。

相似文献

1
Regional localization of DNA probes on the short arm of chromosome 11 using aniridia-Wilms' tumor-associated deletions.利用无虹膜-威尔姆斯瘤相关缺失对11号染色体短臂上的DNA探针进行区域定位。
Hum Genet. 1987 Feb;75(2):180-7. doi: 10.1007/BF00591083.
2
The aniridia-Wilms' tumour association: molecular and genetic analysis of chromosome deletions on the short arm of chromosome 11.无虹膜-威尔姆斯瘤综合征：11号染色体短臂染色体缺失的分子与遗传学分析
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3
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5
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Am J Hum Genet. 1985 Sep;37(5):883-9.
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The c-Ha-ras1, insulin and beta-globin loci map outside the deletion associated with aniridia-Wilms' tumour.c-Ha-ras1、胰岛素和β-珠蛋白基因座定位于与无虹膜-威尔姆斯瘤相关的缺失区域之外。
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Rapid isolation of moderate and highly polymorphic DNA fragments mapping close to WT (Wilms' tumour) and AN2 (aniridia) on chromosome 11.
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Four new DNA markers are assigned to the WAGR region of 11p13: isolation and regional assignment of 112 chromosome 11 anonymous DNA segments.
Genomics. 1988 Oct;3(3):264-71. doi: 10.1016/0888-7543(88)90087-0.

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本文引用的文献

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Hum Genet. 1988 Jun;79(2):186-9. doi: 10.1007/BF00280564.
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Proc Natl Acad Sci U S A. 1988 Jan;85(2):597-601. doi: 10.1073/pnas.85.2.597.
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Human alpha B-crystallin (CRYA2) gene mapped to chromosome 11q12-q23.人类αB-晶状体蛋白（CRYA2）基因定位于11号染色体q12-q23区域。
Hum Genet. 1990 Jul;85(2):237-40. doi: 10.1007/BF00193203.
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Comparative map for mice and humans.小鼠与人类的比较图谱。
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人类胰岛素基因附近的高度多态性区域由简单串联重复序列组成。
Nature. 1982 Jan 7;295(5844):31-5. doi: 10.1038/295031a0.
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Localization of the human insulin gene to the distal end of the short arm of chromosome 11.人类胰岛素基因定位于11号染色体短臂的末端。
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Abnormality of chromosome 11 in patients with features of Beckwith-Wiedemann syndrome.具有贝克威思-维德曼综合征特征的患者中11号染色体异常。
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Hum Genet. 1984;67(2):219-21. doi: 10.1007/BF00273006.
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Expression of recessive alleles by chromosomal mechanisms in retinoblastoma.视网膜母细胞瘤中隐性等位基因通过染色体机制的表达。
Nature. 1983;305(5937):779-84. doi: 10.1038/305779a0.
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Cytological mapping of the human glucose-6-phosphate dehydrogenase gene distal to the fragile-X site suggests a high rate of meiotic recombination across this site.人类葡萄糖-6-磷酸脱氢酶基因在脆性X位点远端的细胞学图谱表明，该位点存在较高的减数分裂重组率。
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The human calcitonin gene is located on the short arm of chromosome 11.人类降钙素基因位于11号染色体的短臂上。
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