人类降钙素基因位于11号染色体的短臂上。
The human calcitonin gene is located on the short arm of chromosome 11.
作者信息
Przepiorka D, Baylin S B, McBride O W, Testa J R, de Bustros A, Nelkin B D
出版信息
Biochem Biophys Res Commun. 1984 Apr 30;120(2):493-9. doi: 10.1016/0006-291x(84)91281-6.
By molecular hybridization of human calcitonin cDNA probes to DNA from human-rodent hybrid cells containing identified human chromosomes, we have mapped the human calcitonin gene to the short arm of chromosome 11. This location has been confirmed by in situ hybridization, which further localized the calcitonin gene to region 11p13-15. The significance of this region regarding gene linkage and possible markers for inherited cancers is discussed.
通过用人降钙素cDNA探针与来自含有已鉴定人类染色体的人-啮齿动物杂交细胞的DNA进行分子杂交，我们已将人降钙素基因定位于11号染色体的短臂上。这一位置已通过原位杂交得到证实，原位杂交进一步将降钙素基因定位到11p13 - 15区域。讨论了该区域在基因连锁和遗传性癌症可能的标志物方面的意义。
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