López-Valverde Nansi, Aragoneses Javier, López-Valverde Antonio, Rodríguez Cinthia, Macedo de Sousa Bruno, Aragoneses Juan Manuel
Department of Medicine and Medical Specialties, Faculty of Health Sciences, Universidad Alcalá de Henares, Madrid, Spain.
Department of Surgery, University of Salamanca, Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain.
Front Bioeng Biotechnol. 2022 Jul 22;10:907589. doi: 10.3389/fbioe.2022.907589. eCollection 2022.
Survival studies of dental implants currently reach high figures. However, considering that the recipients are middle-aged individuals with associated pathologies, research is focused on achieving bioactive surfaces that ensure osseointegration. Chitosan is a biocompatible, degradable polysaccharide with antimicrobial and anti-inflammatory properties, capable of inducing increased growth and fixation of osteoblasts around chitosan-coated titanium. Certain chemical modifications to its structure have been shown to enhance its antibacterial activity and osteoinductive properties and it is generally believed that chitosan-coated dental implants may have enhanced osseointegration capabilities and are likely to become a commercial option in the future. Our review provided an overview of the current concepts and theories of osseointegration and current titanium dental implant surfaces and coatings, with a special focus on the investigation of chitosan-coated implants and a current perspective on the future of titanium dental implant coatings.
目前牙种植体的存活研究成果显著。然而,鉴于接受者多为患有相关疾病的中年个体,研究重点在于实现能确保骨整合的生物活性表面。壳聚糖是一种具有抗菌和抗炎特性的生物相容性可降解多糖,能够促进壳聚糖涂层钛周围成骨细胞的生长和附着增加。对其结构进行的某些化学修饰已显示可增强其抗菌活性和骨诱导特性,人们普遍认为壳聚糖涂层牙种植体可能具有更强的骨整合能力,未来很可能成为一种商业选择。我们的综述概述了当前骨整合的概念和理论以及当前的钛牙种植体表面和涂层,特别着重于对壳聚糖涂层种植体的研究以及对钛牙种植体涂层未来的当前展望。