玉米穗萜 A-E，来自玉米根的新倍半萜。
Zeasesquiterpene A-E, new sesquiterpenes from the roots of Zea mays.
机构信息
School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, China; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
出版信息
Fitoterapia. 2018 Nov;131:15-22. doi: 10.1016/j.fitote.2018.10.004. Epub 2018 Oct 2.
Zeasesquiterpene A-E (1-5), five new sesquiterpenes with two cyclohexanes, were isolated from the roots of Zea mays. Their structures were elucidated on the basis of 1D and 2D NMR spectral data and ECD analysis. A plausible biosynthetic pathway for the compounds (1-6) were hypothesized. All isolated compounds were screened for cytotoxicities against five human cancer cell lines (A549, MDA-MB-231, SK-Hep-1, SNU638 and HCT116) in vitro by MTT assay. Compound 4 showed potential cytotoxic activities against A549 (14.3 μΜ) and SNU638 (9.7 μΜ). By contrast, compound 1 exhibited moderate cytotoxicity to the four human cancer cell lines (A549, SK-Hep-1, SUN638 and HCT116), and the IC values are from 19.5 μΜ to 22.5 μΜ.
玉米烯酮 A-E（1-5），五种新型倍半萜，具有两个环己烷，从玉米根中分离得到。基于 1D 和 2D NMR 谱数据和 ECD 分析确定了它们的结构。提出了化合物（1-6）的可能生物合成途径。通过 MTT 法体外筛选所有分离得到的化合物对五种人癌细胞系（A549、MDA-MB-231、SK-Hep-1、SNU638 和 HCT116）的细胞毒性。化合物 4 对 A549（14.3 μM）和 SNU638（9.7 μM）表现出潜在的细胞毒性。相比之下，化合物 1 对四种人癌细胞系（A549、SK-Hep-1、SNU638 和 HCT116）表现出中等细胞毒性，IC 值为 19.5 μM 至 22.5 μM。
Zotero 插件