Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy.
Italian Sports Medicine Federation (FMSI), Rome, Italy.
Int J Sports Med. 2018 Dec;39(13):1028-1034. doi: 10.1055/a-0634-6387. Epub 2018 Oct 5.
The aim of this study was to investigate the association between the (monocarboxylate transporter 1) A1470T polymorphism and positional roles in a large cohort of professional football players from five different countries. We compared genotype distributions of the A1470T polymorphism between football players (n=694) and non-athlete controls (n=781) from Italy, Poland, Lithuania, Ukraine and Malta, and we analyzed the genotype distributions with respect to the players' positions in the field (e. g. forwards, midfielders, defenders and goalkeepers). Genomic DNA was extracted from either buccal epithelium or peripheral blood using a standard protocol. In the pooled cohort of Italian, Polish, Lithuanian and Ukrainian football players, forwards (n=148) were more likely than controls (n=781) to possess the A allele (χ2=7.067, p=0.029, FDR q value 0.116), with a greater likelihood of having the AA genotype compared with the TT genotype (OR=1.97; C.I.=1.07-3.64; p=0.021, FDR q value 0.086). The MCT1 AA genotype was significantly more frequent in forwards then in controls. Further studies are needed to confirm these findings in other professional football player cohorts.
本研究旨在探讨单羧酸转运蛋白 1（monocarboxylate transporter 1，MCT1）A1470T 多态性与来自五个不同国家的职业足球运动员中位置角色的关联。我们比较了意大利、波兰、立陶宛、乌克兰和马耳他的足球运动员（n=694）和非运动员对照组（n=781）中 A1470T 多态性的基因型分布，并分析了基因型在场上位置（如前锋、中场、后卫和守门员）的分布情况。使用标准方案从口腔上皮或外周血中提取基因组 DNA。在意大利、波兰、立陶宛和乌克兰足球运动员的合并队列中，前锋（n=148）比对照组（n=781）更有可能携带 A 等位基因（χ2=7.067，p=0.029，FDR q 值 0.116），与 TT 基因型相比，AA 基因型的可能性更大（OR=1.97；C.I.=1.07-3.64；p=0.021，FDR q 值 0.086）。MCT1 AA 基因型在前锋中比在对照组中更为常见。需要进一步的研究来确认这些发现是否适用于其他职业足球运动员群体。
