Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 7, Groningen, 9747 AG, The Netherlands.
Analytical Biochemistry, Department of Pharmacy, University of Groningen, Antonius Deusinglaan 1, Groningen, 9713 AV, The Netherlands.
Nat Commun. 2018 Oct 5;9(1):4085. doi: 10.1038/s41467-018-06534-1.
Crucial steps in the miniaturisation of biosensors are the conversion of a biological signal into an electrical current as well as the direct sampling of bodily fluids. Here we show that protein sensors in combination with a nanopore, acting as an electrical transducer, can accurately quantify metabolites in real time directly from nanoliter amounts of blood and other bodily fluids. Incorporation of the nanopore into portable electronic devices will allow developing sensitive, continuous, and non-invasive sensors for metabolites for point-of-care and home diagnostics.
生物传感器微型化的关键步骤是将生物信号转换为电流，以及直接采集体液。在这里，我们展示了蛋白质传感器与纳米孔结合作为电换能器，可以实时从纳升级的血液和其他体液中准确地定量代谢物。将纳米孔集成到便携式电子设备中，将能够开发出用于即时护理和家庭诊断的敏感、连续和非侵入性代谢物传感器。
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