Qinghai Provincial People's Hospital, Trauma orthopedic Department, Xining, 810000, China.
Sci Rep. 2018 Oct 5;8(1):14895. doi: 10.1038/s41598-018-33106-6.
The study aimed to explore the epidemiology and clinical characteristics of chronic osteomyelitis observed in a northern China hospital. Clinical data of 255 patients with chronic osteomyelitis from January 2007 to January 2014 were collected and analyzed, including general information, disease data, treatment and follow-up data. Chronic osteomyelitis is more common in males and in the age group from 41-50 years of age. Common infection sites are the femur, tibiofibular, and hip joint. More g+ than g- bacterial infections were observed, with S. aureus the most commonly observed pathogenic organism. The positive detection rate from debridement bacterial culture is 75.6%. The detection rate when five samples are sent for bacterial culture is 90.6%, with pathogenic bacteria identified in 82.8% of cases. The two-stage debridement method (87.0%) has higher first curative rate than the one-stage debridement method (71.2%). To improve detection rate using bacterial culture, at least five samples are recommended. Treatment of chronic osteomyelitis with two-stage debridement, plus antibiotic-loaded polymethylmethacrylate (PMMA) beads provided good clinical results in this study and is therefore recommended.
本研究旨在探讨中国北方某医院慢性骨髓炎的流行病学和临床特征。收集并分析了 2007 年 1 月至 2014 年 1 月期间 255 例慢性骨髓炎患者的临床资料，包括一般信息、疾病数据、治疗和随访数据。慢性骨髓炎在男性和 41-50 岁年龄组中更为常见。常见的感染部位是股骨、胫腓骨和髋关节。观察到更多的 g+菌感染，金黄色葡萄球菌是最常见的病原体。清创细菌培养的阳性检出率为 75.6%。送 5 份标本进行细菌培养的检出率为 90.6%，82.8%的病例可鉴定出病原菌。二期清创（87.0%）的首次治愈率高于一期清创（71.2%）。为提高细菌培养的检出率，建议至少送 5 份标本。本研究中，采用二期清创术联合载抗生素聚甲基丙烯酸甲酯（PMMA）珠治疗慢性骨髓炎，取得了良好的临床效果，因此推荐使用。
