Gelb L D, Dohner D E, Gershon A A, Steinberg S P, Waner J L, Takahashi M, Dennehy P H, Brown A E
J Infect Dis. 1987 Apr;155(4):633-40. doi: 10.1093/infdis/155.4.633.
Restriction endonuclease analysis of varicella-zoster virus (VZV) DNA has been used in unraveling the complex epidemiology of VZV infections in individuals immunized with a live, attenuated varicella virus vaccine. Early rashes appearing within the first six weeks after vaccination are invariably due to vaccine virus. True breakthrough infections with wild-type VZV also occur in vaccinees. Five cases of zoster have been seen in leukemic children vaccinated while in remission. One case appeared 22 months after vaccination in the same general area as the inoculation. The virus isolated was vaccine derived. A second case of zoster appeared in a dermatome unrelated to the sites of vaccination approximately 19 months after apparently natural varicella. This virus was wild type. Vaccine virus can therefore establish latency and can later reactivate as herpes zoster.
水痘带状疱疹病毒（VZV）DNA的限制性内切酶分析已被用于阐明接种减毒活水痘病毒疫苗个体中VZV感染的复杂流行病学。接种疫苗后六周内出现的早期皮疹总是由疫苗病毒引起的。疫苗接种者也会发生野生型VZV的真正突破性感染。在白血病儿童缓解期接种疫苗时，已发现5例带状疱疹病例。1例在接种疫苗后22个月出现在接种部位附近的同一区域。分离出的病毒源自疫苗。另一例带状疱疹出现在明显自然感染水痘约19个月后，位于与接种部位无关的皮节。该病毒为野生型。因此，疫苗病毒可以建立潜伏状态，并在以后重新激活成为带状疱疹。
