Department of Psychology, University of Hong Kong, Hong Kong, Hong Kong; Department of Psychology, The Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Department of Psychology, University of Hong Kong, Hong Kong, Hong Kong.
Trends Cogn Sci. 2018 Nov;22(11):1038-1049. doi: 10.1016/j.tics.2018.09.001. Epub 2018 Oct 3.
There has been a recent growth in investigations into the neural mechanisms underlying the problems recalling specific autobiographical events that are a core feature of emotional disorders. In this review we provide the first synthesis of this literature, taking into account brain as well as cognitive mechanisms. We suggest that these problems are driven by idiosyncratic activation in areas of the brain associated with assigning salience and self-relevance to emotional memories. Other areas associated with inhibiting distraction and constructing vivid memory representations are also important. Each of these mechanisms may work independently or in concert with one another. Importantly, this interaction between mechanisms may differ between diagnostic and demographic groups such that similar problems in specificity may be characterised by different mechanisms. Given this challenge, neuroimaging may prove useful in identifying patient-specific biomarkers for interventions.
最近，人们对情绪障碍的核心特征——回忆特定自传体事件的神经机制进行了大量研究。在这篇综述中，我们综合考虑了大脑和认知机制，首次对这一文献进行了综述。我们认为，这些问题是由与给情绪记忆赋予显著意义和自我相关性相关的大脑区域的特殊激活所驱动的。与抑制分心和构建生动的记忆表征相关的其他区域也很重要。这些机制中的每一个都可能独立或协同作用。重要的是，这种机制之间的相互作用可能因诊断和人口统计学群体而异，因此特定的特异性问题可能由不同的机制来描述。考虑到这一挑战，神经影像学可能有助于为干预措施确定患者特异性的生物标志物。
