Yetz J M, Letvin N L
J Gen Virol. 1987 Feb;68 ( Pt 2):573-6. doi: 10.1099/0022-1317-68-2-573.
Type D retroviruses have recently been shown to induce a wasting syndrome with associated lymphadenopathy, thymic atrophy and transient decreased peripheral blood lymphocyte blastogenic responsiveness in juvenile macaque monkeys. The replication in vitro of D/New England virus was assessed in various lymphocyte subpopulations to determine the possible pathogenesis of the immune dysfunction induced by this virus. While D/New England did not replicate in cultured T lymphocytes or induce any demonstrable dysfunction of T cells in vitro, it did grow in the cells of the B lymphocyte lineage. D/New England growth occurred in vitro in African Burkitt's lymphoma and pre-B cell lines, but not in Epstein-Barr virus-transformed normal B lymphocytes. The infection of a restricted B lymphocyte population by this primate type D retrovirus may play a role in the aetiology of the immune abnormalities which it induces.
最近研究表明，D型逆转录病毒可在幼年猕猴中诱发消瘦综合征，并伴有淋巴结病、胸腺萎缩以及外周血淋巴细胞增殖反应性短暂降低。对D/新英格兰病毒在体外不同淋巴细胞亚群中的复制情况进行了评估，以确定该病毒诱发免疫功能障碍的可能发病机制。虽然D/新英格兰病毒在培养的T淋巴细胞中不复制，且在体外不会诱发T细胞出现任何可证实的功能障碍，但它确实能在B淋巴细胞系的细胞中生长。D/新英格兰病毒在体外可在非洲伯基特淋巴瘤细胞和前B细胞系中生长，但在爱泼斯坦-巴尔病毒转化的正常B淋巴细胞中不生长。这种灵长类D型逆转录病毒对特定B淋巴细胞群体的感染可能在其诱发的免疫异常病因学中起作用。
