Darville J M, Harbour D A, Hill T J, Blyth W A
J Gen Virol. 1987 Mar;68 ( Pt 3):907-11. doi: 10.1099/0022-1317-68-3-907.
The stability of the restriction endonuclease profile of herpes simplex virus type 1 strain SC16 in mice was studied. Virus isolated from skin during acute infection was compared with that from latently infected ganglia and with that from recrudescent lesions induced by trauma. In another experiment virus serially passaged only in skin was compared with virus that had also replicated in the nervous system. The loss or gain of specific restriction sites was not observed but in some cases the mobility of certain fragments decreased.
研究了单纯疱疹病毒1型SC16株在小鼠体内限制性内切酶图谱的稳定性。将急性感染期间从皮肤分离的病毒与潜伏感染神经节的病毒以及创伤诱导的复发损伤的病毒进行了比较。在另一项实验中，仅在皮肤中连续传代的病毒与也在神经系统中复制的病毒进行了比较。未观察到特定限制性酶切位点的丢失或获得，但在某些情况下，某些片段的迁移率降低。
