Obulareddy Vishnu Teja, Chava Vijay Kumar, Nagarakanti Sreenivas
Department of Periodontology, Narayana Dental College and Hospital, Andhra Pradesh, India.
Contemp Clin Dent. 2018 Sep;9(Suppl 2):S299-S304. doi: 10.4103/ccd.ccd_289_18.
Periodontitis and stress are among the areas of increasing interest over the past two decades. Early detection of these diseases plays a crucial role in successful therapy. Cortisol is a protein which was found to be consistently associated with both.
The present study was aimed to evaluate saliva cortisol levels (SCLs) in chronic periodontitis (CP) patients with and without stress.
In this cross-sectional study, saliva samples were collected and cortisol levels were determined using ELISA method in 92 participants. The participants were divided into four groups based on periodontal condition (number of teeth present, plaque index (PI), bleeding on probing (BOP), probing pocket depth, and clinical attachment level) and stress levels into Group 1 (no periodontitis and no stress), Group 2 (with periodontitis and no stress), Group 3 (without periodontitis and with stress), and Group 4 (with periodontitis and stress).
Overall, 92 adult participants (41 males and 51 females) were included in the study. Participants with stress and periodontitis have high mean SCL when compared to other groups (Group 1: 15.01 ± 2.62, Group 2: 31.92 ± 6.80, Group 3: 34.47 ± 13.47, and Group 4: 60.13 ± 6.68). Group I shows a significant negative correlation of cortisol to BOP, stress to PI, and stress to cortisol level, whereas there is a positive correlation of SCL to PD in Group 4 which is not statistically significant.
SCL showed difference among the groups. SCL were associated with both CP and psychological stress. Increase in inflammation and stress levels enhances the SCL.
在过去二十年中，牙周炎和压力成为越来越受关注的领域。这些疾病的早期检测对成功治疗起着关键作用。皮质醇是一种被发现与两者都持续相关的蛋白质。
本研究旨在评估有压力和无压力的慢性牙周炎（CP）患者的唾液皮质醇水平（SCLs）。
在这项横断面研究中，收集了92名参与者的唾液样本，并使用酶联免疫吸附测定法（ELISA）测定皮质醇水平。参与者根据牙周状况（牙齿数量、菌斑指数（PI）、探诊出血（BOP）、探诊袋深度和临床附着水平）和压力水平分为四组：第1组（无牙周炎且无压力）、第2组（有牙周炎且无压力）、第3组（无牙周炎且有压力）和第4组（有牙周炎且有压力）。
总体而言，92名成年参与者（41名男性和51名女性）纳入了研究。与其他组相比，有压力和牙周炎的参与者平均SCL较高（第1组：15.01±2.62，第2组：31.92±6.80，第3组：34.47±13.47，第4组：60.13±6.68）。第1组显示皮质醇与BOP、压力与PI以及压力与皮质醇水平之间存在显著负相关，而第4组中SCL与PD呈正相关，但无统计学意义。
SCL在各组之间存在差异。SCL与CP和心理压力均相关。炎症和压力水平的增加会提高SCL。
