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马传染性贫血病毒在平行持续感染期间的病程及变异程度

Course and extent of variation of equine infectious anemia virus during parallel persistent infections.

作者信息

Payne S L, Salinovich O, Nauman S M, Issel C J, Montelaro R C

出版信息

J Virol. 1987 Apr;61(4):1266-70. doi: 10.1128/JVI.61.4.1266-1270.1987.

DOI:10.1128/JVI.61.4.1266-1270.1987
PMID:3029423
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC254092/
Abstract

Comparisons of peptide and oligonucleotide maps of glycoproteins and RNA from nine isolates of equine infectious anemia virus (EIAV) that were generated during parallel infections of two Shetland ponies revealed that each isolate was structurally unique. Each EIAV isolate contained a unique subset of variant peptides, oligonucleotides, or both, indicating that structural variation in EIAV is a random and noncumulative process and that a large spectrum of possible EIAV variants can be generated in infected animals.

摘要

对两匹设得兰矮种马同时感染期间产生的9株马传染性贫血病毒（EIAV）的糖蛋白和RNA的肽图谱及寡核苷酸图谱进行比较，结果显示每株病毒在结构上都是独特的。每株EIAV都含有一组独特的变异肽、寡核苷酸或两者皆有，这表明EIAV的结构变异是一个随机且非累积的过程，并且在受感染动物体内可以产生大量可能的EIAV变体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3693/254092/366a7766cf14/jvirol00095-0332-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3693/254092/366a7766cf14/jvirol00095-0332-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3693/254092/366a7766cf14/jvirol00095-0332-a.jpg

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本文引用的文献

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Isolation of human T-cell leukemia virus in acquired immune deficiency syndrome (AIDS).在获得性免疫缺陷综合征（艾滋病）中分离出人T细胞白血病病毒。
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一株 EIAV 野外分离株显示出比目前报道的马属慢病毒科更高水平的亚型变异性。
Retrovirology. 2009 Oct 20;6:95. doi: 10.1186/1742-4690-6-95.
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Equine infectious anemia virus genomic evolution in progressor and nonprogressor ponies.进行性和非进行性小马中马传染性贫血病毒的基因组进化
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In vivo dynamics of equine infectious anemia viruses emerging during febrile episodes: insertions/duplications at the principal neutralizing domain.发热期出现的马传染性贫血病毒的体内动态：主要中和结构域的插入/重复
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In vivo replicative status and envelope heterogeneity of equine infectious anemia virus in an inapparent carrier.马传染性贫血病毒在隐性携带者体内的体内复制状态和包膜异质性
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