Yang Chunbo, Kelaini Sophia, Caines Rachel, Margariti Andriana
Centre for Experimental Medicine, Queens University Belfast, Belfast, United Kingdom.
Front Physiol. 2018 Sep 20;9:1310. doi: 10.3389/fphys.2018.01310. eCollection 2018.
Diabetes is one of the major health care problems worldwide leading to huge suffering and burden to patients and society. Diabetes is also considered as a cardiovascular disorder because of the correlation between diabetes and an increased incidence of cardiovascular disease. Vascular endothelial cell dysfunction is a major mediator of diabetic vascular complications. It has been established that diabetes contributes to significant alteration of the gene expression profile of vascular endothelial cells. Post-transcriptional regulation by RNA binding proteins (RBPs) plays an important role in the alteration of gene expression profile under diabetic conditions. The review focuses on the roles and mechanisms of critical RBPs toward diabetic vascular endothelial dysfunction. Deeper understanding of the post- transcriptional regulation by RBPs could lead to new therapeutic strategies against diabetic manifestation in the future.
糖尿病是全球主要的医疗保健问题之一，给患者和社会带来巨大痛苦和负担。由于糖尿病与心血管疾病发病率增加之间的相关性，糖尿病也被视为一种心血管疾病。血管内皮细胞功能障碍是糖尿病血管并发症的主要介导因素。已经证实，糖尿病会导致血管内皮细胞基因表达谱的显著改变。RNA结合蛋白（RBPs）的转录后调控在糖尿病条件下基因表达谱的改变中起重要作用。本文综述聚焦于关键RBPs在糖尿病血管内皮功能障碍中的作用和机制。更深入地了解RBPs的转录后调控可能会在未来带来针对糖尿病表现的新治疗策略。
