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Bilateral Femoral Head Avascular Necrosis with Physiological Doses of Steroids.

作者信息

Rajput Smit, Kulshreshtha Bindu

机构信息

Department of Endocrinology, PGIMER, Dr. RML Hospital, New Delhi, India.

出版信息

Indian J Endocrinol Metab. 2018 Sep-Oct;22(5):710-711. doi: 10.4103/ijem.IJEM_97_18.

DOI:10.4103/ijem.IJEM_97_18
PMID:30294585
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6166565/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3f0/6166565/bc8b8a48eb23/IJEM-22-710-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3f0/6166565/71598c112ae1/IJEM-22-710-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3f0/6166565/bc8b8a48eb23/IJEM-22-710-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3f0/6166565/71598c112ae1/IJEM-22-710-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3f0/6166565/bc8b8a48eb23/IJEM-22-710-g002.jpg

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Avascular necrosis of the femoral head due to low-dose corticosteroid used in a patient with panhypopituitarism: A case report and literature review.全垂体功能减退患者使用低剂量皮质类固醇导致的股骨头缺血性坏死：一例报告及文献综述
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本文引用的文献

1
Bilateral femoral head avascular necrosis with a very low dose of oral corticosteroid used for panhypopituitarism.双侧股骨头缺血性坏死，使用极低剂量口服糖皮质激素治疗全垂体功能减退症。
BMJ Case Rep. 2016 Jan 13;2016:bcr2015212803. doi: 10.1136/bcr-2015-212803.
2
Low levels of steroid-metabolizing hepatic enzyme (cytochrome P450 3A) activity may elevate responsiveness to steroids and may increase risk of steroid-induced osteonecrosis even with low glucocorticoid dose.肝脏中类固醇代谢酶（细胞色素P450 3A）活性水平较低，可能会提高对类固醇的反应性，即使使用低剂量糖皮质激素，也可能增加类固醇诱导的骨坏死风险。
J Orthop Sci. 2009 Nov;14(6):794-800. doi: 10.1007/s00776-009-1400-5. Epub 2009 Dec 8.
3
人工股骨头置换治疗股骨头缺血性坏死的疗效
Medicine (Baltimore). 2019 Apr;98(17):e15411. doi: 10.1097/MD.0000000000015411.
Glucocorticoids in osteonecrosis of the femoral head: a new understanding of the mechanisms of action.
糖皮质激素与股骨头坏死：对作用机制的新认识
J Steroid Biochem Mol Biol. 2009 Apr;114(3-5):121-8. doi: 10.1016/j.jsbmb.2009.02.007. Epub 2009 Feb 21.
4
Avascular necrosis of bone complicating corticosteroid replacement therapy.皮质类固醇替代治疗并发的骨缺血性坏死。
Ann Rheum Dis. 1983 Jun;42(3):276-9. doi: 10.1136/ard.42.3.276.
5
Early avascular necrosis of the femoral head. Report of a case and review of the literature.股骨头早期缺血性坏死。1例报告并文献复习。
J Bone Joint Surg Br. 1986 May;68(3):414-7. doi: 10.1302/0301-620X.68B3.3525571.
6
Across-study evaluation of association between steroid dose and bolus steroids and avascular necrosis of bone.关于类固醇剂量、冲击性类固醇与骨缺血性坏死之间关联的跨研究评估。
Lancet. 1987 Apr 18;1(8538):902-6. doi: 10.1016/s0140-6736(87)92870-4.