β-内啡肽：猫体内耐受性的发展及其被5-羟色氨酸逆转的情况
beta-Endorphin: development of tolerance and its reversal by 5-hydroxytryptophan in cats.
作者信息
Hosobuchi Y, Meglio M, Adams J E, Li C H
出版信息
Proc Natl Acad Sci U S A. 1977 Sep;74(9):4017-9. doi: 10.1073/pnas.74.9.4017.
Abstract
Tolerance to beta-endorphin developed acutely in cats if the administration of the peptide was repeated within the first 24 hr. The tolerance was reversed immediately by systemic administration of the serotonin precursor, 5-hydroxytryptophan. It was further shown that 5-hydroxytryptophan potentiates the analgesic effect of the subliminal dose of beta-endorphin.
摘要
如果在最初24小时内重复给予肽类物质，猫会迅速产生对β-内啡肽的耐受性。通过全身给予血清素前体5-羟色氨酸，耐受性会立即逆转。进一步研究表明，5-羟色氨酸可增强阈下剂量β-内啡肽的镇痛效果。
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