Chen Hangbin, Yang Huan, Li Mengqing, Peng Haojie, Guo Weibin, Li Meng
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China.
Ainuo Blessing Veterinary Hospital, Guangzhou, Guangdong, China.
Front Vet Sci. 2023 Feb 14;10:1117313. doi: 10.3389/fvets.2023.1117313. eCollection 2023.
To determine if oral gabapentin decreases the minimum alveolar concentration (MAC) of isoflurane in cats.
Prospective, randomized, blinded, crossover, and experimental study.
A total of six healthy adult cats (three male, three female) aged 18-42 months, weighing 3.31 ± 0.26 kg.
Cats were randomly given oral gabapentin (100 mg cat) or placebo 2 h before starting MAC determination, with the crossover treatment given at least 7 days apart. Anesthesia was induced and maintained with isoflurane in oxygen. Isoflurane MAC was determined in duplicate using an iterative bracketing technique and tail clamp method. Hemodynamic and other vital variables were recorded at each stable isoflurane concentration and were compared between gabapentin and placebo treatments at lowest end-tidal isoflurane concentration when cats did not respond to tail clamping. A paired -test was used to compare normally distributed data, and a Wilcoxon signed-rank test was applied for non-normally distributed data. Significance was set at < 0.05. Data are mean ± standard deviation.
Isoflurane MAC in the gabapentin treatment was 1.02 ± 0.11%, which was significantly lower than that in the placebo treatment (1.49 ± 0.12%; < 0.001), decreasing by 31.58 ± 6.94%. No significant differences were found in cardiovascular and other vital variables between treatments.
Oral administration of gabapentin 2 h before starting MAC determination had a significant isoflurane MAC-sparing effect in cats with no observed hemodynamic benefit.
确定口服加巴喷丁是否会降低猫异氟烷的最低肺泡有效浓度（MAC）。
前瞻性、随机、双盲、交叉和实验性研究。
总共6只健康成年猫（3只雄性，3只雌性），年龄18 - 42个月，体重3.31±0.26千克。
在开始测定MAC前2小时，猫被随机给予口服加巴喷丁（每只猫100毫克）或安慰剂，交叉治疗间隔至少7天。用异氟烷在氧气中诱导并维持麻醉。使用迭代括值技术和尾夹法重复测定异氟烷MAC。在每个稳定的异氟烷浓度下记录血流动力学和其他重要变量，并在猫对尾夹无反应时，比较加巴喷丁和安慰剂治疗在最低呼气末异氟烷浓度时的情况。配对t检验用于比较正态分布数据，Wilcoxon符号秩检验用于非正态分布数据。显著性设定为P<0.05。数据为平均值±标准差。
加巴喷丁治疗组的异氟烷MAC为1.02±0.11%，显著低于安慰剂治疗组（1.49±0.12%；P<0.001），降低了31.58±6.94%。治疗组之间在心血管和其他重要变量方面未发现显著差异。
在开始测定MAC前2小时口服加巴喷丁对猫有显著的异氟烷MAC节省效应，但未观察到血流动力学益处。
