Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospita, Seongnam, Korea.
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Sci Rep. 2018 Oct 8;8(1):14977. doi: 10.1038/s41598-018-33361-7.
This study aimed to examine the prognostic value of C-reactive protein (CRP)/albumin (ALB) ratio among patients who were admitted to the intensive care unit (ICU) in predicting 30-day mortality rate. This retrospective cohort study was conducted by examining the medical records of adult patients who were admitted to the ICU at Seoul National University Bundang Hospital between 1 January 2012 and 31 December 2016. Data from 6,972 individuals were included in the final analysis, and 547 of these individuals (7.1%) died within 30 days after their ICU admission. The multivariable Cox regression analysis revealed that an increase of 1 for the CRP/ALB ratio was associated with an 11% increase in the risk of 30-day mortality (hazard ratio: 1.11, 95% confidence interval: 1.09-1.14, P < 0.001). However, the area under curve of CRP/ALB ratio in receiver operating characteristic analysis was lower than that of Acute Physiologic Assessment and Chronic Health Evaluation (APACHE) II, Charlson comorbidity index, or serum albumin alone. Although an elevated CRP/ALB ratio on ICU admission was an independent risk factor for 30-day mortality rate, the predictive power of CRP/ALB ratio was lower than that of albumin alone, APACHE II, and Charlson comorbidity index.
本研究旨在探讨 C 反应蛋白（CRP）/白蛋白（ALB）比值在重症监护病房（ICU）住院患者中预测 30 天死亡率的预后价值。这项回顾性队列研究通过检查 2012 年 1 月 1 日至 2016 年 12 月 31 日期间在首尔国立大学盆唐医院 ICU 住院的成年患者的病历进行。最终分析纳入了 6972 名个体的数据，其中 547 名（7.1%）个体在 ICU 入院后 30 天内死亡。多变量 Cox 回归分析显示，CRP/ALB 比值增加 1 与 30 天死亡率增加 11%相关（危险比：1.11，95%置信区间：1.09-1.14，P<0.001）。然而，CRP/ALB 比值在受试者工作特征分析中的曲线下面积低于急性生理学和慢性健康评估（APACHE）II、Charlson 合并症指数或单独血清白蛋白。尽管 ICU 入院时 CRP/ALB 比值升高是 30 天死亡率的独立危险因素，但 CRP/ALB 比值的预测能力低于单独的白蛋白、APACHE II 和 Charlson 合并症指数。
