Cheng Ziqian, Zou Xiaohan, Jin Yang, Gao Shuohui, Lv Jiayin, Li Bingjin, Cui Ranji
Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, China.
Department of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, China.
Front Cell Neurosci. 2018 Sep 21;12:325. doi: 10.3389/fncel.2018.00325. eCollection 2018.
Krüppel-like factor 4 (KLF), a member of the family of zinc-finger transcription factors, is widely expressed in range of tissues that play multiple functions. Emerging evidence suggest KLF's critical regulatory effect on the neurophysiological and neuropathological processes of Alzheimer's disease (AD), indicating that KLF might be a potential therapeutic target of neurodegenerative diseases. In this review, we will summarize relevant studies and illuminate the regulatory role of KLF in the neuroinflammation, neuronal apoptosis, axon regeneration and iron accumulation to clarify KLF's status in the pathogenesis of AD.
Krüppel样因子4（KLF）是锌指转录因子家族的成员，在发挥多种功能的一系列组织中广泛表达。新出现的证据表明KLF对阿尔茨海默病（AD）的神经生理和神经病理过程具有关键的调节作用，这表明KLF可能是神经退行性疾病的潜在治疗靶点。在这篇综述中，我们将总结相关研究，并阐明KLF在神经炎症、神经元凋亡、轴突再生和铁蓄积中的调节作用，以明确KLF在AD发病机制中的地位。
