The Role of KLF in Alzheimer's Disease.

Krüppel-like factor 4 (KLF), a member of the family of zinc-finger transcription factors, is widely expressed in range of tissues that play multiple functions. Emerging evidence suggest KLF's critical regulatory effect on the neurophysiological and neuropathological processes of Alzheimer's disease (AD), indicating that KLF might be a potential therapeutic target of neurodegenerative diseases. In this review, we will summarize relevant studies and illuminate the regulatory role of KLF in the neuroinflammation, neuronal apoptosis, axon regeneration and iron accumulation to clarify KLF's status in the pathogenesis of AD.